ACYLAMINOTHIAZOLE DERIVATIVES, THEIR PREPARATION AND APPLICATION AS INHIBITORS OF B-AMILOYD PEPTIDES PRODUCTION Russian patent published in 2009 - IPC C07D277/46 C07D417/12 A61K31/426 A61K31/427 A61K31/4427 A61K31/381 A61P25/16 A61P25/28 

FIELD: chemistry, medicine.

SUBSTANCE: in the general formula (I): X is oxygen atom; R₁ is C_1-10-alkyl , substituted if necessary by phenyl or thienyl group; or R₁ is C_3-7-cycloalkyl, thienyl, pyridinyl; the thienyl groups can be substituted if necessary by 1-2 C_1-3-alkyl groups; phenyl can be substituted if necessary by 1-2 halogen atoms; R₂ is C_1-6-alkyl; or R₂ is C_3-7-cycloalkyl, phenyl or pyridinyl; phenyl if necessary can be substituted by one or more halogen atoms or by the CN, C_1-3-alkyl, C_1-3-alkoxyl, C_1-3-fluoroalkyl groups; R₃ is C_1-6-alkyl; R₄ is hydrogen atom or C_1-6-alkyl; R₅ and R₅' are independently of each other the hydrogen atom, hydroxyl; or R₅ and R₅' form together the oxo-group; n is integer value in the range from 0 to 3; R₆ is independently of each other hydrogen atom, halogen atom, C_1-3-alkyl, C_1-3-alkoxyl.

EFFECT: compounds of present invention can find application as pharmaceutical for pathology treatment where the inhibitor of β-amiloyd peptide β-A4 is useful.

8 cl, 1 tbl, 7 ex