1-AMINOMETHYL-α,ω-ALKADIINE SYNTHESIS METHOD Russian patent published in 2010 - IPC C07C11/00 C07C11/12 C07C11/22 

FIELD: chemistry.

SUBSTANCE: invention relates to a method for synthesis of 1-aminomethyl-α,ω-alkadiines of general formula (1): , where R₂N = piperidyl, morpholyl, N-methylpiperazyl, characterised by that α,ω-diacetylenes HC≡C-(CH₂)_n-C≡CH, where n=4, 6, 8, react with gem-diamines R₂NCH₂NR₂, where R₂N is as defined above, in the presence of a copper (I) chloride catalyst (CuCl), taken in molar ratio α,ω-diacetylene: gem-diamine: CuCl=10:10: (0.3-0.7),preferably 10:10:0.5 mmol without a solvent at temperature of 80°C and atmospheric pressure for 4-5 hours. 1-aminomethyl-α,ω-alkadiines can be used in fine organic synthesis and particularly in synthesis of scarce polycyclic compounds, as well as in synthesis of biologically active substances.

EFFECT: method increases output of the desired products.

1 cl, 1 ex, 1 tbl