FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to novel compounds of formula (1) 
, in form of trans- or cis-isomers, or their mixture, where R1 is selected from 
, 
and 
; R7 stands for lower alkyl; R8 stands for lower alkyl; X represents >C=O or >SO2; R9 and R11 represent hydrogen or together form double bond; R10 and R12 are independently selected from hydrogen or lower alkyl; m stands for 1 or 2; n stands for 0, 1 or 2 and their pharmaceutically acceptable salts. Invention also relates to pharmaceutical composition and to application of said compounds, as well as compounds of formula (I), where R1 represents 
(R2, R3, R4, R5 and R6 each is independently selected from hydrogen, lower alkyl, lower alkoxy group or halogen; on condition that R2, R3, R4, R5 and R6 do not represent hydrogen), for treatment and/or prevention of DPP-IV-associated diseases.
EFFECT: obtaining novel compounds for treatment and/or prevention of DPP-IV-associated diseases.
14 cl, 1 tbl, 33 ex
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