NOVEL CYCLOHEXANE DERIVATIVES Russian patent published in 2010 - IPC C07C311/20 C07C233/23 C07D233/84 C07D277/36 C07D231/18 A61K31/18 A61K31/137 A61K31/4164 A61K31/426 A61K31/415 A61P3/06 A61P3/10 

FIELD: chemistry.

SUBSTANCE: invention relates to novel hexafluoroisopropanol substituted derivatives of cyclohexane of formula (I) with LXRα- and/or LXRβ agonist modulation properties, as well as to their pharmaceutically acceptable salts. In formula (I) R¹ denotes hydrogen, lower alkyl, fluoro-lower alkyl, lower alkyl-carbonyl, fluoro-lower alkyl-carbonyl, phenyl-lower alkyl, C₃-C₆-cycloalkyl-lower alkyl, C₃-C₆-cycloalkylcarbonyl or C₃-C₆-cycloalkyl-lower alkyl-carbonyl; R² denotes hydrogen or lower alkyl; R³ denotes lower alkyl, phenyl-lower alkyl, where phenyl is possibly substituted with lower alkoxycarbonyl, lower alkoxycarbonyl, or if X represents a single bond and m is not equal to 0, R³ can also denote a hydroxy group; R⁴ denotes phenyl or heterocyclyl, where heterocyclyl is a five-member aromatic heterocyclic ring containing two heteroatoms selected from nitrogen and sulphur, optionally substituted with 1-3 substitutes independently selected from a group which includes lower alkyl and halogen; X denotes a single bond, SO₂, CO or C(O)O; m equals 0, 1, 2 or 3; n equals 0 or 1. The invention also relates to a pharmaceutical composition containing formula (I) compounds.

EFFECT: novel compounds have useful biological properties.

20 cl, 35 ex