5-HYDROXYBENZOTHIAZOLE DERIVATIVES AS β-ADRENORECEPTOR AGONISTS Russian patent published in 2010 - IPC C07D277/68 A61K31/428 A61P11/00 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula in free form or in form of a pharmaceutically acceptable salt, where T denotes C₁-C₁₀alkyl which is substituted in one position with a -NR¹R² group or C₃-C₁₅carboxylic group selected from indan, phenyl, C₃-C₈cycloalkyl, wherein said C₃-C₁₅carboxylic group is optionally substituted in one or two positions with a halogen group, -NR³R⁴ or C₁-C₁₀alkoxy group, or T denotes C₃-C₁₅carboxylic group selected from indan, phenyl, C₅cycloalkyl which is optionally substituted in one or two positions with a C₁-C₁₀alkyl group, C₅cycloalkyl or C₁-C₁₀alkoxy group which is optionally substituted in one position with phenyl, and R¹, R² independently denote C₁-C₁₀alkyl or phenyl, and R³, R⁴ independently denote C₁-C₁₀alkyl. The formula I compound has β₂-adrenoreceptor agonist activity.

EFFECT: more effective use as an active ingredient of a pharmaceutical composition.

7 cl, 1 tbl, 3 ex