FIELD: organic chemistry, biochemistry, medicine, pharmacy.
SUBSTANCE: invention relates to new derivatives of urea of the formula (I): 
wherein A means heteroaryl that is taken among the group that comprises: 
and 
wherein radicals B, R1 and R2 have values given in description. These compound possess capacity to inhibit activity of enzyme RAF kinase and to inhibit growth of tumor cells. Also, invention relates to a method for inhibition of activity of RAF kinase in mammal body and to pharmaceutical compositions based on compounds of the formula (I). Invention provides preparing new derivatives of urea possessing valuable pharmaceutical properties.
EFFECT: improved method for inhibition, valuable properties of compounds and composition.
25 cl, 6 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR INHIBITION OF RAF KINASE-MEDIATED GROWTH OF TUMOR CELLS, HETEROCYCLIC UREA DERIVATIVES (VARIANTS), PHARMACEUTICAL COMPOSITION (VARIANTS) | 1998 |
|
RU2232015C2 |
| SYMMETRIC AND ASYMMETRIC DERIVATIVES OF DIPHENYLUREA (VARIANTS), PHARMACEUTICAL COMPOSITION, METHOD FOR INHIBITION OF RAF KINASE- MEDIATED TUMOR CELLS PROLIFERATION | 1998 |
|
RU2247109C9 |
| DERIVATIVES OF UREA (VARIANTS), PHARMACEUTICAL COMPOSITION (VARIANTS) AND METHOD FOR TREATMENT OF DISEASES ASSOCIATED WITH CANCER CELLS GROWTH (VARIANTS) | 2000 |
|
RU2319693C9 |
| SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS | 2012 |
|
RU2569635C9 |
| NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | 2013 |
|
RU2660429C2 |
| N3-ALKYLATED BENZIMIDAZOLE DERIVATIVES AS MEK INHIBITORS | 2003 |
|
RU2300528C2 |
| PYRROLO-PYRROLE COMPOSITIONS AS ACTIVATORS OF PYRUVATE KINASE (PKR) | 2018 |
|
RU2736217C2 |
| OPTIONALLY CONDENSED HETEROCYCLYL-SUBSTITUTED PYRIMIDINE DERIVATIVES SUITABLE FOR TREATING INFLAMMATORY, METABOLIC, ONCOLOGICAL AND AUTOIMMUNE DISEASES | 2015 |
|
RU2734261C2 |
| METHOD FOR SYNTHESIS OF SUBSTITUTED UREA COMPOUNDS | 2015 |
|
RU2760719C2 |
| CHEMICAL COMPOUNDS AS INTERLEUKIN-1 INHIBITORS | 2018 |
|
RU2792143C2 |
