2,4-DI(HETERO)ARYLAMINOPYRIMIDINE DERIVATIVES AS ZAP-70 INHIBITORS Russian patent published in 2010 - IPC C07D405/12 C07D403/12 C07D239/48 A61K31/506 A61K31/505 A61P35/00 A61P37/00 A61P29/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel derivatives of 2,4-di(hetero)arylaminopyrimidine of general formula I or its pharmaceutically acceptable salt, possessing properties of ZAP-70 inhibitors. In compounds of formula I: Z stands for =CR²-; each of radicals R⁰ and R¹ represents hydrogen; R² represents (C₁-C₄)alkoxy; R³ represents -SO₂NH₂; or R¹ and R² form together with C-atoms, to which they are bound, 5-7-member non-aromatic carbocyclic or heterocyclic residue, where said heterocyclic residue includes 1 or 2 heteroatoms, selected from N and O, and heterocyclic residue, containing 1-2 atoms of oxygen can be substituted with fluorine atoms; R⁴ and R⁶ represent hydrogen, R⁵ represents hudrogen, halogen, (C₁-C₄)alkyl or CF₃; one of R⁷, R⁸ and R⁹ represents NR¹⁰R¹¹, and one or two others represent hydrogen, halogen, COOH, CF₃ or (C₁-C₄)alkyl; R¹⁰ and R¹¹ independently represents hydrogen or (C₁-C₄)alkyl. Invention also relates to methods of obtaining compounds.

EFFECT: compounds can be applied, for instance in case of acute or chronic rejection of organ or tissue, in treatment of atherosclerosis and other diseases, when inhibition of ZAP-70 is of importance.

9 cl, 7 tbl, 150 ex