PHENYLAMINOPYRIMIDINE COMPOUNDS AND USES THEREOF Russian patent published in 2013 - IPC C07D413/12 C07D403/12 C07D239/42 C07D413/14 C07D401/12 C07D417/12 C07D401/14 A61K31/444 A61K31/506 A61K31/505 A61K31/541 A61K31/5377 A61P3/00 A61P31/12 A61P37/06 A61P9/00 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel phenylaminopyrimidine compounds of formula I, which are JAK kinase inhibitors. In particular, these compounds selectively act on JAK2 kinase. The compounds can be used to treat diseases such as immunological and inflammatory diseases; hyperproliferative diseases, myeloproliferative diseases; viral diseases; metabolic diseases; and vascular diseases. In the compound of formula I , Q and Z are independently selected from N and CR¹; R¹ is independently selected from hydrogen, halogen, R², OR², OH, R⁴, OR⁴, CN, CF₃, (CH₂)nN(R²)₂, where n equals 1,2 or 3, NO₂, R²R⁴, NR²SO₂R³, COR⁴, NR²COR³, CO₂H, CO₂R², NR²COR⁴, R²CN, R²OH, R²OR³ and OR⁵R⁴; or two substitutes R¹ together with carbon atoms with which they are bonded form an unsaturated 5- or 6-member heterocyclic ring containing 1-4 N atoms; R² is C_1-4alkyl; R⁴ is R², C_2-4alkenyl or phenyl; R⁴ is NH₂, NHR², N(R¹)₂, substituted or unsubstituted morpholine, CH₂morpholine, substituted or unsubstituted thiomorpholine, substituted or unsubstituted thiomorpholino-1-oxide, substituted or unsubstituted thiomorpholino-1,1-dioxide, substituted or unsubstituted piperazinyl, substituted or unsubstituted piperidinyl, substituted or unsubstituted pyridinyl, substituted or unsubstituted pyrrolidinyl, substituted or unsubstituted pyrrolyl, substituted or unsubstituted oxazolyl, substituted or unsubstituted imidazolyl, substituted or tetrahydrofuranyl unsubstituted and substituted or unsubstituted tetrahydropyranyl; R⁵ is C_2-4alkylene; R⁶-R⁹ are independently selected from H, R^XCN, halogen, substituted or unsubstituted C_1-4alkyl, OR¹, CO₂R¹, N(R¹)₂, NO₂ and CON(R¹)₂, wherein at least one of R⁶-R⁹ is R^XCN; the rest of the values of the radicals are given in the claim.

EFFECT: high efficiency of treatment.

29 cl, 7 dwg, 2 tbl, 93 ex