FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to compounds of formula IB 
, where radicals R1-R5 have values, given in invention formula. In range of claimed invention also described are pharmaceutical compositions, which include compounds of IB formula, and methods of application of such compounds and compositions for treatment of different malfunctions, mainly selected from immune response reactions.
EFFECT: compounds by claimed invention have inhibiting action with respect to proteinkinases and, in particular with respect to JAK-3, ROCK or Aurora kinases.
55 cl, 6 tbl, 4 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 4-AMINOQUINAZOLINE ANTAGONISTS OF SELECTIVE SODIUM AND CALCIUM ION CHANNELS | 2004 |
|
RU2378260C2 |
| QUINAZOLINE EFFECTIVE AS ION CHANNEL MODULATORS | 2005 |
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| CASPASE INHIBITOR PRODRUGS | 2006 |
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| PYRROLOPYRAZINES SUITABLE AS AURORA A KINASE INHIBITORS | 2005 |
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| METHOD OF OBTAINING MODULATORS OF CYSTIC FIBROUSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | 2010 |
|
RU2543714C2 |
| METHOD OF PRODUCING BIARYLUREA AND ANALOGUES THEREOF | 2006 |
|
RU2431630C2 |
| COMPOSITIONS USEFUL AS INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | 2007 |
|
RU2470012C2 |
| DIAMINOTRIAZOLE COMPOUNDS USED AS PROTEIN KINASE INHIBITORS | 2005 |
|
RU2443700C2 |
| PYRAZOLE DERIVATIVES, USEFUL AS INHIBITORS OF PROTEIN KINASE | 2001 |
|
RU2332415C2 |
| PYRROLOPYRIMIDINES USED AS PROTEIN KINASE INHIBITORS | 2006 |
|
RU2434871C2 |
