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(19)

(11)

2 443 700

(13)

(51)

IPC

C07D401/14(2006-01-01)

C07D403/14(2006-01-01)

C07D405/14(2006-01-01)

C07D413/14(2006-01-01)

C07D487/08(2006-01-01)

A61K31/506(2006-01-01)

A61P37/08(2006-01-01)

(21) (22)

Application

2007114293/04, 2005-09-19

(24)

Start date

2005-09-19

(22)

Actual filing date

2005-09-19

(45)

Published

2012-02-27

(72)

Inventor

Salituro Franchesko G.Ledebur Mark V.Ledford BrajanVan Tszjan'Pirs Al'Bert K.Daffi Dzhon P.Messersmit Dehvid

(73)

Holder

Verteks Farmas'Jutikalz Inkorporejted

DIAMINOTRIAZOLE COMPOUNDS USED AS PROTEIN KINASE INHIBITORS Russian patent published in 2012 - IPC C07D401/14 C07D403/14 C07D405/14 C07D413/14 C07D487/08 A61K31/506 A61P37/08

Abstract RU 2443700 C2

FIELD: chemistry.

SUBSTANCE: described are novel diaminotriazole compounds of general formula

(values of radicals are given in the claim), pharmaceutically acceptable salts thereof, a pharmaceutical composition containing said compounds, a method of inhibiting JAK2 and JAK3 kinase activity and use of the novel compounds to produce a medicinal agent for treating several diseases.

EFFECT: high efficiency of the compounds.

19 cl, 3 tbl, 26 ex

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RU 2 443 700 C2

Authors

Salituro Franchesko G.

Ledebur Mark V.

Ledford Brajan

Van Tszjan'

Pirs Al'Bert K.

Daffi Dzhon P.

Messersmit Dehvid

Dates

2012-02-27—Published

2005-09-19—Filed