INACTIVATED VACCINE AGAINST HEPATITIS A VIRUS Russian patent published in 2010 - IPC A61K39/29 

Abstract RU 2404804 C2

FIELD: medicine.

SUBSTANCE: invention relates to agents for immunoprophylaxis of infection diseases, in particular to production of vaccine preparations against virus of hepatitis A and may be used in medical and microbiological industry and in antiepidemic practice. Antigen of hepatitis A virus is produced on the basis of strain of hepatitis virus No. VBA-07 on transferred cells of green monkey kidneys 4647 at the following ratio of vaccine components content in one dose: antigen VGA of at least 80 EIA units for adults or at least 40 EIA units for children, formaldehyde of not more than 0.15 mg/ml, aluminium hydroxide (AL+3) from 0.35 to 0.65 mg/ml.

EFFECT: vaccine AGALVAK has simpler technology and short cycle of its production as a result of using quick-growing and highly productive strain-producer of antigen of hepatitis A virus with preservation of high immunogenic activity.

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Authors

Muntjanova Marija Alekseevna

Nemtsov Jurij Vasil'Evich

Krjuk Natal'Ja Ivanovna

Jashin Valerij Viktorovich

Kuslij Aleksandr Georgievich

Nikulin Leonid Georgievich

Molokeev Aleksej Vladimirovich

Mironenko Vjacheslav Vladimirovich

Jasudis Galina Vladimirovna

Guseva Irina Aleksandrovna

Dates

2010-11-27Published

2009-02-10Filed