FIELD: medicine.
SUBSTANCE: invention relates to agents for immunoprophylaxis of infection diseases, in particular to production of vaccine preparations against virus of hepatitis A and may be used in medical and microbiological industry and in antiepidemic practice. Antigen of hepatitis A virus is produced on the basis of strain of hepatitis virus No. VBA-07 on transferred cells of green monkey kidneys 4647 at the following ratio of vaccine components content in one dose: antigen VGA of at least 80 EIA units for adults or at least 40 EIA units for children, formaldehyde of not more than 0.15 mg/ml, aluminium hydroxide (AL+3) from 0.35 to 0.65 mg/ml.
EFFECT: vaccine AGALVAK has simpler technology and short cycle of its production as a result of using quick-growing and highly productive strain-producer of antigen of hepatitis A virus with preservation of high immunogenic activity.
3 tbl, 2 ex
Title | Year | Author | Number |
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HEPATITIS TYPE A VIRUS STRAIN FOR PRODUCING VACCINES AND DIAGNOSTIC PREPARATIONS | 2008 |
|
RU2405037C2 |
METHOD FOR PREPARING INACTIVATED VACCINE AGAINST HEPATITIS A VIRUS | 2006 |
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RU2314125C1 |
Virus hepatitis A hominis STRAIN FOR PRODUCING OF VACCINE AND DIAGNOSTIC PREPARATIONS | 2005 |
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RU2306336C2 |
STRAIN OF HEPATITE A VIRUS FOR ACCUMULATING BIOMASS USED FOR PRODUCING PREVENTIVE AND DIAGNOSIS PREPARATIONS | 0 |
|
SU1474171A1 |
VIRAL VACCINE | 2003 |
|
RU2268067C2 |
METHOD OF PREPARING VACCINE AGAINST HEPATITIS A | 1989 |
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SU1672635A1 |
STRAIN OF VIRUS HEPATITIS A HOMINIS FOR PREPARATION OF VACCINE AND DIAGNOSTIC PREPARATIONS | 0 |
|
SU1806190A3 |
STRAIN OF HYBRID CULTURED CELL OF ANIMAL RATTUS NORVEGICUS USED FOR PREPARING MONOCLONAL ANTIBODIES RAISED TO HUMAN HEPATITIS A VIRUS | 1997 |
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RU2142507C1 |
STRAIN OF THE HYBRID CULTURED ANIMAL CELL MUS MUSCULUS L - A PRODUCER OF MONOCLONAL ANTIBODY RAISED TO AUJESZKY'S DISEASE VIRUS, STRAIN UNIIEV-18B | 1995 |
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RU2092554C1 |
TABLETED LIVE RECOMBINANT BIVACCINE "REVAKS VKT" AGAINST NATURAL SMALLPOX AND HEPATITIS B AND METHOD FOR ITS PREPARING | 2002 |
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RU2242246C2 |
Authors
Dates
2010-11-27—Published
2009-02-10—Filed