FIELD: chemistry.
SUBSTANCE: invention relates to a novel improved method for synthesis of N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidine-sulphone)-N'-isonictinoyl hydrazide, which can be used as a substance of medicinal agents for treating and preventing secondary immunodeficiencies, mycobacterial and viral infections, by reacting 6- methyluracil-5-sulphochloride with isonicotinic acid hydraside, characterised by that reaction of 6- methyluracil-5-sulphochloride with isonicotinic acid hydrazide in equimolar ratio takes place in a γ- butyrolacton medium at 90-100°C for 2 hours, followed by purification of the desired product in aqueous ammonium solution at 75-80°C and extraction from the solution at pH 4.5.
EFFECT: method shortens duration the process and increases output of the desired product.
1 cl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINE-SULPHONE)-N′-ISONICTINOYL HYDRAZIDE | 2010 |
|
RU2455301C2 |
| METHOD OF PRODUCING N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINE-SULPHONE)-N'-ISONICOTINOYL HYDRAZIDE | 2011 |
|
RU2458059C1 |
| METHOD FOR PREPARING N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINSULFON)-N'-ISONICOTINO YL HYDRAZIDE | 2003 |
|
RU2235723C1 |
| SILVER SALT OF N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRIMIDINESULPHONE)-N'-ISONICOTINOYLHYDRAZIDE, WHICH EXHIBITS IMMUNOTROPIC, ANTIMICROBIAL, ANTIFUNGAL (ANTIMYCOTIC) ACTIVITY AND MEDICINAL AGENT BASED ON SAID SALT | 2008 |
|
RU2368609C1 |
| IMMUNOMODULATING AGENT "IZOFON" SHOWING ANTIMYCOBACTERIAL ACTIVITY, METHOD OF ITS PREPARING AND USING | 1997 |
|
RU2141322C1 |
| 6-ALKYL-5-(2-ISONICOTINOYLSULFOHYDRAZOYL)URACIL HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF | 2003 |
|
RU2264396C2 |
| N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRIMIDINESULFONE)-N′- ISONICOTINOYL HYDRAZIDE DISODIUM SALT ELICITING ANTIBACTERIAL AND IMMUNOTROPIC ACTIVITY AND MEDICINAL AGENT BASED ON THEREOF | 1999 |
|
RU2191015C2 |
| MEDICINAL AGENT | 2002 |
|
RU2223100C1 |
| IMMUNOTROPIC N, N '-(SULPHONYLDI-1,4-PHENYLENE)BIS[(N",N'"-DIMETHYL)METHYLIMINOMETHANE]1,2,3,4-TETRAHYDRO-6-METHYL-2,4-DIOXO-5-PYRIMIDINESULPHONATE | 2007 |
|
RU2357960C1 |
| N,N'-(SULFONYLDI-1,4-PHENYLENE)-BIS-(N'',N''-DIMETHYLFORM- -AMIDINE)-1,2,3,4-TETRAHYDRO-6-METHYL-2,4-DIOXO-5-PYRIMIDINE SULFONATE STIMULATING CELLULAR METABOLISM AND SHOWING IMMUNOTROPIC AND ANTIBACTERIAL ACTIVITY | 1997 |
|
RU2136668C1 |
