FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention relates to a method for preparing N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyromidinsulfon)-N'-isonicotinoyl hydrazide. Method involves interaction of 6-methyluracil-5-sulfochloride with isonicotinic acid hydrazide in the presence of dioxane as the reaction activating agent in the mole ratio of reagents = 1:1.5:2.5, respectively, in anhydrous ethyl acetate medium, at temperature 50-75oC for 6 h, not less, followed by treatment of obtained product with aqueous dimethylformamide at 70-80oC and pH 6, isolation and dehydration of the end product. N-(6-Methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinsulfon)-N'-isonicotinoyl hydrazide is used in medicine as active component of the preparation using for prophylaxis and treatment of secondary immunodeficiency states of infectious and somatic pathology, in treatment of bacterial and viral infections. Invention provides elevating yield of the end product, reducing process time, reducing labor intensity and consumptions.
EFFECT: improved preparing method.
1 cl, 4 tbl, 5 ex
| Title |
Year |
Author |
Number |
| METHOD OF OBTAINING AND PURIFYING N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINE-SULPHONE)-N'-ISONICTINOYL HYDRAZIDE |
2009 |
- Makarov Vladimir Vasil'Evich
- Kondjukov Ivan Zinov'Evich
- Valeshnij Sergej Ivanovich
|
RU2404977C1 |
| METHOD OF PRODUCING N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINE-SULPHONE)-N′-ISONICTINOYL HYDRAZIDE |
2010 |
- Makarov Vladimir Vasil'Evich
- Valeshnij Sergej Ivanovich
- Kondjukov Ivan Zinov'Evich
- Il'In Vladimir Petrovich
|
RU2455301C2 |
| METHOD OF PRODUCING N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINE-SULPHONE)-N'-ISONICOTINOYL HYDRAZIDE |
2011 |
- Makarov Vladimir Vasil'Evich
- Valeshnij Sergej Ivanovich
- Il'In Vladimir Petrovich
- Mikhajlov Viktor Vasil'Evich
- Flikshtejn Aleksandr Izrailovich
- Goloshchapov Konstantin Veniaminovich
|
RU2458059C1 |
| SILVER SALT OF N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRIMIDINESULPHONE)-N'-ISONICOTINOYLHYDRAZIDE, WHICH EXHIBITS IMMUNOTROPIC, ANTIMICROBIAL, ANTIFUNGAL (ANTIMYCOTIC) ACTIVITY AND MEDICINAL AGENT BASED ON SAID SALT |
2008 |
- Rasnetsov Lev Davidovich
- Shvartsman Jakov Judelevich
- Jashnova Ol'Ga Konstantinovna
- Mel'Nikova Nina Borisovna
- Chudetskaja Julija Viktorovna
- Volkov Aleksandr Aleksandrovich
|
RU2368609C1 |
| IMMUNOMODULATING AGENT "IZOFON" SHOWING ANTIMYCOBACTERIAL ACTIVITY, METHOD OF ITS PREPARING AND USING |
1997 |
- Goloshchapov N.M.
- Goloshchapova E.N.
- Filipskikh T.P.
- Michurina E.A.
- Kostjuk L.E.
- Khaitov R.M.
- Tsyvkina G.I.
- Grishin V.K.
- Stukalov N.A.
- Reshetov A.L.
|
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1999 |
- Goloshchapov N.M.
- Filipskikh T.P.
- Kostjuk L.E.
- Goloshchapova E.N.
- Michurina E.A.
- Reshetov A.L.
- Zavarzin A.A.
|
RU2191015C2 |
| 6-ALKYL-5-(2-ISONICOTINOYLSULFOHYDRAZOYL)URACIL HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
2003 |
- Reshetov A.L.
- Vereshchagina I.A.
|
RU2264396C2 |
| IMMUNOTROPIC N, N '-(SULPHONYLDI-1,4-PHENYLENE)BIS[(N",N'"-DIMETHYL)METHYLIMINOMETHANE]1,2,3,4-TETRAHYDRO-6-METHYL-2,4-DIOXO-5-PYRIMIDINESULPHONATE |
2007 |
- Khaitov Musa Rakhimovich
- Tsyvkina Galina Ivanovna
- Sedova Svetlana Nikolaevna
- Gomzhin Andrej Mikhajlovich
- Savel'Ev Evgenij Aleksandrovich
- Khimich Galina Nikolaevna
- Khimich Nikolaj Nikolaevich
|
RU2357960C1 |
| N,N'-(SULFONYLDI-1,4-PHENYLENE)-BIS-(N'',N''-DIMETHYLFORM- -AMIDINE)-1,2,3,4-TETRAHYDRO-6-METHYL-2,4-DIOXO-5-PYRIMIDINE SULFONATE STIMULATING CELLULAR METABOLISM AND SHOWING IMMUNOTROPIC AND ANTIBACTERIAL ACTIVITY |
1997 |
- Goloshchapov N.M.
- Michurina E.A.
- Filipskikh T.P.
- Goloshchapova E.N.
- Kostjuk L.E.
- Sudareva T.T.
- Khaitov R.M.
- Tsyvkina G.I.
- Reshetov A.L.
|
RU2136668C1 |
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1996 |
- Goloshchapov N.M.
- Sudareva T.T.
- Kostjuk L.E.
- Filipskikh T.P.
- Goloshchapova E.N.
- Zaika G.F.
- Kuznetsov V.A.
|
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