FIELD: chemistry.
SUBSTANCE: invention relates to a method of producing N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidine-sulphone)-N'-isonicotinoyl hydrazide - an immunostimulant which has an effect on all parts of the immune system, is active with respect to mycobacteria and is used in treating diseases on the background of secondary immunodeficiency conditions: tuberculosis, leprosy, clamidiosis, herpetic infection, by reacting 6-methyluracil-5-sulphochloride with isonicotinic acid hydrazide,m characterised by that the solvent used is an aliphatic alcohol: ethyl, isopropyl and methyl alcohol.
EFFECT: method reduces process hazard, reduces material consumption, reduces labour input, prevents formation of liquid organic wastes and improved environmental friendliness of the process.
| Title |
Year |
Author |
Number |
| METHOD OF OBTAINING AND PURIFYING N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINE-SULPHONE)-N'-ISONICTINOYL HYDRAZIDE |
2009 |
- Makarov Vladimir Vasil'Evich
- Kondjukov Ivan Zinov'Evich
- Valeshnij Sergej Ivanovich
|
RU2404977C1 |
| METHOD OF PRODUCING N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINE-SULPHONE)-N′-ISONICTINOYL HYDRAZIDE |
2010 |
- Makarov Vladimir Vasil'Evich
- Valeshnij Sergej Ivanovich
- Kondjukov Ivan Zinov'Evich
- Il'In Vladimir Petrovich
|
RU2455301C2 |
| METHOD FOR PREPARING N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINSULFON)-N'-ISONICOTINO YL HYDRAZIDE |
2003 |
- Artemov V.A.
- Valeshnij S.I.
- Il'In V.P.
- Kolganov E.V.
- Kostjuk L.E.
- Lajshev V.Z.
- Makarov V.V.
- Mikhajlov V.V.
- Michurina E.A.
- Smirnov S.P.
|
RU2235723C1 |
| IMMUNOMODULATING AGENT "IZOFON" SHOWING ANTIMYCOBACTERIAL ACTIVITY, METHOD OF ITS PREPARING AND USING |
1997 |
- Goloshchapov N.M.
- Goloshchapova E.N.
- Filipskikh T.P.
- Michurina E.A.
- Kostjuk L.E.
- Khaitov R.M.
- Tsyvkina G.I.
- Grishin V.K.
- Stukalov N.A.
- Reshetov A.L.
|
RU2141322C1 |
| SILVER SALT OF N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRIMIDINESULPHONE)-N'-ISONICOTINOYLHYDRAZIDE, WHICH EXHIBITS IMMUNOTROPIC, ANTIMICROBIAL, ANTIFUNGAL (ANTIMYCOTIC) ACTIVITY AND MEDICINAL AGENT BASED ON SAID SALT |
2008 |
- Rasnetsov Lev Davidovich
- Shvartsman Jakov Judelevich
- Jashnova Ol'Ga Konstantinovna
- Mel'Nikova Nina Borisovna
- Chudetskaja Julija Viktorovna
- Volkov Aleksandr Aleksandrovich
|
RU2368609C1 |
| 6-ALKYL-5-(2-ISONICOTINOYLSULFOHYDRAZOYL)URACIL HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
2003 |
- Reshetov A.L.
- Vereshchagina I.A.
|
RU2264396C2 |
| N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRIMIDINESULFONE)-N′- ISONICOTINOYL HYDRAZIDE DISODIUM SALT ELICITING ANTIBACTERIAL AND IMMUNOTROPIC ACTIVITY AND MEDICINAL AGENT BASED ON THEREOF |
1999 |
- Goloshchapov N.M.
- Filipskikh T.P.
- Kostjuk L.E.
- Goloshchapova E.N.
- Michurina E.A.
- Reshetov A.L.
- Zavarzin A.A.
|
RU2191015C2 |
| METHOD OF SYNTHESIS OF 6-METHYLURACIL-5-SULFO- CHLORIDE |
2001 |
- Makarov V.V.
- Drobysheva N.E.
- Abdrakhmanov I.Sh.
- Firkin A.I.
|
RU2204555C2 |
| METHOD OF OBTAINING N-(ISO)NICOTINOYL- γ -AMINOBUTYRIC ACID AND ITS SODIUM OR POTASSIUM SALT |
2007 |
- Gordon Elena Petrovna
- Mitrokhin Anatolij Mikhajlovich
- Nikolenko Valerij Sergeevich
- Poddubnyj Igor' Sergeevich
|
RU2337097C1 |
| N,N'-(SULFONYLDI-1,4-PHENYLENE)-BIS-(N'',N''-DIMETHYLFORM- -AMIDINE)-1,2,3,4-TETRAHYDRO-6-METHYL-2,4-DIOXO-5-PYRIMIDINE SULFONATE STIMULATING CELLULAR METABOLISM AND SHOWING IMMUNOTROPIC AND ANTIBACTERIAL ACTIVITY |
1997 |
- Goloshchapov N.M.
- Michurina E.A.
- Filipskikh T.P.
- Goloshchapova E.N.
- Kostjuk L.E.
- Sudareva T.T.
- Khaitov R.M.
- Tsyvkina G.I.
- Reshetov A.L.
|
RU2136668C1 |
