FIELD: medicine. SUBSTANCE: invention relates to the novel immunomodulating drug "Izofon" showing an antimycobacterial activity, method of its preparing and using. Method involves the interaction of equimolar amount of 6-methyluracil-5-sulfochloride and isonicotinic acid hydrazide in absolute acetonitrile at 81 C, filtration, precipitate dissolving in hot water, filtration, addition of NH4OH to filtrate up to pH 7, precipitate preparing and its crystallization from dimethylformamide (DMFA). Obtained substance is N-(6-methyl-2,4-dioxo-1,2,3,4-tetrahydro- -5-pyrimidinesulfone)-N-isonicotinoylhydrazide hydrate that shows an antimycobacterial activity used orally and by parenteral route. The developed new immunomodulating agent showing an antimycobacterial activity can be used in secondary immunodeficiency and mycobacteriosis also. EFFECT: new agent indicated above, enhanced an antimycobacterial activity. 4 cl, 3 tbl, 5 ex
| Title |
Year |
Author |
Number |
| N,N'-(SULFONYLDI-1,4-PHENYLENE)-BIS-(N'',N''-DIMETHYLFORM- -AMIDINE)-1,2,3,4-TETRAHYDRO-6-METHYL-2,4-DIOXO-5-PYRIMIDINE SULFONATE STIMULATING CELLULAR METABOLISM AND SHOWING IMMUNOTROPIC AND ANTIBACTERIAL ACTIVITY |
1997 |
- Goloshchapov N.M.
- Michurina E.A.
- Filipskikh T.P.
- Goloshchapova E.N.
- Kostjuk L.E.
- Sudareva T.T.
- Khaitov R.M.
- Tsyvkina G.I.
- Reshetov A.L.
|
RU2136668C1 |
| N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRIMIDINESULFONE)-N′- ISONICOTINOYL HYDRAZIDE DISODIUM SALT ELICITING ANTIBACTERIAL AND IMMUNOTROPIC ACTIVITY AND MEDICINAL AGENT BASED ON THEREOF |
1999 |
- Goloshchapov N.M.
- Filipskikh T.P.
- Kostjuk L.E.
- Goloshchapova E.N.
- Michurina E.A.
- Reshetov A.L.
- Zavarzin A.A.
|
RU2191015C2 |
| METHOD FOR PREPARING N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINSULFON)-N'-ISONICOTINO YL HYDRAZIDE |
2003 |
- Artemov V.A.
- Valeshnij S.I.
- Il'In V.P.
- Kolganov E.V.
- Kostjuk L.E.
- Lajshev V.Z.
- Makarov V.V.
- Mikhajlov V.V.
- Michurina E.A.
- Smirnov S.P.
|
RU2235723C1 |
| SILVER SALT OF N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5H-PYRIMIDINESULPHONE)-N'-ISONICOTINOYLHYDRAZIDE, WHICH EXHIBITS IMMUNOTROPIC, ANTIMICROBIAL, ANTIFUNGAL (ANTIMYCOTIC) ACTIVITY AND MEDICINAL AGENT BASED ON SAID SALT |
2008 |
- Rasnetsov Lev Davidovich
- Shvartsman Jakov Judelevich
- Jashnova Ol'Ga Konstantinovna
- Mel'Nikova Nina Borisovna
- Chudetskaja Julija Viktorovna
- Volkov Aleksandr Aleksandrovich
|
RU2368609C1 |
| N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINYL-5-SULFONYL)PYRAZINE- -2-CARBOXAMIDE POSSESSING ANTI LEPROTIC AND ANTITUBERCULOSIS AND IMMUNOTROPIC ACTIVITY, METHOD FOR THEIR PRODUCTION |
1996 |
- Goloshchapov N.M.
- Sudareva T.T.
- Kostjuk L.E.
- Filipskikh T.P.
- Goloshchapova E.N.
- Zaika G.F.
- Kuznetsov V.A.
|
RU2102390C1 |
| 6-ALKYL-5-(2-ISONICOTINOYLSULFOHYDRAZOYL)URACIL HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
2003 |
- Reshetov A.L.
- Vereshchagina I.A.
|
RU2264396C2 |
| METHOD OF PRODUCING N-(6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINE-SULPHONE)-N'-ISONICOTINOYL HYDRAZIDE |
2011 |
- Makarov Vladimir Vasil'Evich
- Valeshnij Sergej Ivanovich
- Il'In Vladimir Petrovich
- Mikhajlov Viktor Vasil'Evich
- Flikshtejn Aleksandr Izrailovich
- Goloshchapov Konstantin Veniaminovich
|
RU2458059C1 |
| ISONICOTINIC ACID HYDRAZIDE OROTATE HAVING ANTIBACTERIAL AND IMMUNOTROPIC ACTIVITIES |
1990 |
- Goloshchapov N.M.
- Sudareva T.T.
- Kostjuk L.E.
- Filipskikh T.P.
- Goloshchapova E.N.
- Ershov A.P.
- Zaika G.F.
- Pokrovskaja V.A.
- Semenova S.V.
- Merzljakova I.N.
|
RU2044728C1 |
| IMMUNOTROPIC N, N '-(SULPHONYLDI-1,4-PHENYLENE)BIS[(N",N'"-DIMETHYL)METHYLIMINOMETHANE]1,2,3,4-TETRAHYDRO-6-METHYL-2,4-DIOXO-5-PYRIMIDINESULPHONATE |
2007 |
- Khaitov Musa Rakhimovich
- Tsyvkina Galina Ivanovna
- Sedova Svetlana Nikolaevna
- Gomzhin Andrej Mikhajlovich
- Savel'Ev Evgenij Aleksandrovich
- Khimich Galina Nikolaevna
- Khimich Nikolaj Nikolaevich
|
RU2357960C1 |
| 4,4'-SULFONYL-BIS-(N,N'-DIMETHYLAMMONIOMETHYLENEANILINE)-CHLORIDE, 6-METHYL-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDINE-5-SULFONATE, PHARMACEUTICAL COMPOSITION BASED ON THEREOF |
2004 |
- Dmitriev Aleksandr Ivanovich
|
RU2275356C2 |
