2,4-DI(AMINOPHENYL)PYRIMIDINES AS PLK-KINASE INHIBITORS Russian patent published in 2010 - IPC C07D403/12 C07D403/14 C07D401/12 C07D401/14 C07D405/12 C07D413/12 C07D239/48 A61K31/506 A61K31/5513 A61K31/553 A61P29/00 A61P35/00 A61P37/00 

FIELD: medicine.

SUBSTANCE: invention refers to new compounds exhibiting antiproliferative activity of formula (1) where W means N or C-R₂; X means -NH-; Y means CH; Z means halogen, -NO₂, C₂-C₃alkynyl-, halogen-C₁-C₃alkyl- and -C(=O)-C₁-C₃alkyl, A means a group of formula (i), (ii) or (iii) Q1 means phenyl; B¹, B², B³ and B⁴ independently mean C-R^gR^h, N-Rⁱ or O; R¹ means hydrogen; R² means a residue specified from the group including hydrogen, halogen and -OR⁴; R^a, R^b, R^c, R^d, R^e and R^f independently mean hydrogen; R^g and R^h independently mean a residue specified from the group including hydrogen, =O, -OR⁴ and -NR⁴C(=O)R⁵; or mean optionally a residue monosubstituted or twice-substituted with equal or different substitutes and specified from the group including C₁-C₆alkyl and phenyl, the substitute/substitutes is/are specified from the group including R^8/, -OR⁴, -C(=O)R⁴, -C(=O)OR⁴ and -C(=O)NR⁴R⁵ where R^8/ and other values of radicals are specified in the patent claim, optionally in the form of their pharmacologically noncontaminating acid addition salts. The invention also concerns a pharmaceutical composition.

EFFECT: new compounds have effective biological properties.

8 cl, 6 dwg, 1086 ex