FIELD: chemistry.
SUBSTANCE: invention relates to a method for synthesis of derivatives in the family of pyrrole[3,4-c]carbazole, and specifically to a method for synthesis of novel 2-R1-6-R2-5-aryl-pyrrole[3,4-c]carbazole-1,3(2H,6H)-diones of formula I: 
, where R1=:C1-C6 alkylphenyl, C1-C6 dialkylphenyl, C1-C6 dialkylphenyl dioxy C1-C6 alkyl; R2=C1-C6 alkyl; Ar=phenyl, C1-C6 alkyl phenyl, oxyalkylphenyl, halophenyl, having potential anticancer activity. The method involves reacting 1-R2-indolin-2-ones of general formula 
II with oxalyl chloride and 4-aryl-3-butenoic acid of general formula 
III, reacting the formed 3-(2-chloro-1-R2-1H-indol-3-yl)-4-[(E)-2-arylethenyl]furan-2,5-diones of general formula 
IV with R1-amines of general formula R1-NH2 V, and then photocyclisation of the formed 1-alkyl-3-(2-chloro-1-R2 -1H-indol-3-yl)-4-[(E)-2-arylethenyl]-1H-pyrrole-2,5-diones of general formula 
VI, where R1, R2 and Ar assume values listed above.
EFFECT: method for synthesis of novel derivatives having potential anticancer activity.
| Title | Year | Author | Number |
|---|---|---|---|
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|
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|
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| INDOLOPYRROLOCARBAZOLE DERIVATIVES OF SUGARS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND METHOD OF INHIBITION OF TUMOR PROLIFERATION | 1997 |
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| 1,3-DIOXO-2,3-DIHYDRO-1H-PYRROLO[3,4-C]QUINOLINES (VARIANTS), PHARMACEUTICAL COMPOSITIONS (VARIANTS), METHOD FOR THEIR PREPARING (VARIANTS) AND METHOD FOR TREATMENT (VARIANTS) | 2003 |
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