INDOLOPYRROLOCARBAZOLE DERIVATIVES OF SUGARS, PHARMACEUTICAL COMPOSITION CONTAINING THEREOF AND METHOD OF INHIBITION OF TUMOR PROLIFERATION Russian patent published in 2001 - IPC

FIELD: organic chemistry, pharmacy. SUBSTANCE: invention relates to novel indolopyrrolocarbazole derivatives of sugars of the general formula (I) where one of R₁ and R₁a means hydrogen atom but other is not hydrogen atom; R₂ and mean independently hydrogen atom, OH; R₃ and mean independently hydrogen atom, OH; R₄ and mean independently hydrogen atom, OH, azido-group, NH₂, halogen atom; mean independently H, OH, azido-group, NR₉R₁₀, halogen atom, C(O)Ra, SR, OSO₂Rc, OR or in common they form =O under condition that R₂,R₃,R₄,R₅ and and all are not hydrogen atom simultaneously; R means hydrogen atom, C_1-7-alkyl, heterocyclic 6-membered ring containing 1 or 2 nitrogen atoms as heteroatoms being indicated C_1-7-alkyl can be substituted with phenyl; Ra means OH; Rc means C_1-7-alkyl; R₆ means hydrogen atom, C_1-7-alkyl, OH, NH₂ being indicated C_1-7-alkyl can be substituted with phenyl which in turn can be substituted with C_1-7-alkyl; R₇ and R₈ in common mean O; R₉ and R₁₀ mean independently hydrogen atom or in common with nitrogen atom to which they are bound form cyclic 6-membered nonaromatic ring containing one or two heteroatoms taken among the group N, O; and mean independently H, halogen atom, -C(O)Ra under condition that and are not 1,11-dichloro-group and under condition that when X₂ and each means H, X₁ and then each means independently H or halogen atom; R₁ means hexose; R₇ and R₈ in common mean O and each of R₂,R₅ and R₄ means OH; and each means H; Q means NH and in this case each of R₃ and R₆ is not NH₂ and R₃ is not methoxy-group when R₆ means H; W means C; Q means NH, O or S; or its pharmaceutically acceptable salt. Compounds of the formula (I) show activity with respect to topoisomerase-1 and can be used for inhibition of proliferation of tumor cells eliciting antitumor effect. Invention describes pharmaceutical composition and method of inhibition of tumor growth also. EFFECT: new compounds, valuable antitumor activity. 18 cl, 3 tbl, 106 ex