DERIVATIVES OF GLYCOSIDES OF INDOLO[2,3-A]-PYRROLO[3,4-C]CARBAZOL-5,7-DIONES ELICITING CYTOTOXIC AND ANTITUMOR ACTIVITY Russian patent published in 2005 - IPC

FIELD: organic chemistry, medicine, oncology.

SUBSTANCE: invention relates to new glycosides of indolo[2,3-a]-pyrrolo[3,4-c]carbazol-5,7-diones of the general formula (1)

wherein: -R₁ means residue of mono- or disaccharide in pyranose form taken among the group: D-Rib, L-Ara, D-Xyl, D-Gal, D-Glc, D-Lac; -R₂ means hydrogen atom, methyl group or residue of mono- or disaccharide; -R₃ means hydrogen atom, hydroxyl group, amino-group or formamido-group; each -X₁ and -X₂ means independently of one another hydrogen atom or bromine atom under condition that they can't mean hydrogen atom simultaneously and under condition also that if R₁ means disaccharide residue then R₂ differs from hydrogen atom. Prepared derivatives show, in particular, cytotoxic and antitumor activity against melanoma B16 and Ehrlich tumor.

EFFECT: valuable medicinal properties of derivatives.

3 cl, 3 tbl, 2 dwg, 8 ex