EXTRUDED SOFT CAPSULE, METHOD TO PREPARE CAPSULE-FILLING SOLUTION, CAPSULE MANUFACTURE METHOD AND METHOD TO RAISE DENSITY OF AGAR COATING Russian patent published in 2010 - IPC A61K9/48 A61K36/484 A61K36/41 A61K33/30 A61K33/00 A61K31/592 A61K31/355 A61K31/202 A61K31/201 A61K31/122 A61K31/07 A61P43/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to chemical and pharmaceutical industry, notably to development of capsule with turgescent coating made of agar-agar with or without addition of water-soluble biologically active compounds, filled with oily solutions of oil-soluble vitamins and/or herbal oily extracts and/or fatty oils or fatty oils mixtures. Solution for encapsulation is prepared in the following manner: plastifier is added to water, stirred till complete dissolution, then agar-agar is added and left to turgesce at 15-40°C during 0.1-10 hours, preferably about 0.5-2 hours; then obtained mixture is stirred at 70-99°C, preferably at 80-98°C, most preferably at 95°C till mixture will become homogenous and transparent. Then capsules are manufactured as follows: solution is delivered in extruder which extrudes capsules at 77-99°C, preferably at 82-90°C, most preferably at 86°C; extruding rate is 1-10 capsules per second, preferably 3-6 capsules per second, cooling fluid's temperature is 3-15°C. Higher density of capsule agar covering is achieved by subsequent exposure to solution of polyol during 0.1-30 minutes, preferably 0.5 minutes, then to ethanol, preferably 95%, during 1-20 minutes, preferably 5 minutes.

EFFECT: capsules are resistant to temperature and humidity gradients, free of animal proteins thus excluding prionic infections.

16 cl, 27 ex