ARYLSULPHONAMIDE-SUBSTITUTED HYDROXAMIC ACID DERIVATIVES AS MATRIX METALLOPROTEINASE INHIBITORS Russian patent published in 2010 - IPC C07C311/18 C07H3/02 A61K31/7004 A61P11/00 A61Q19/08 A61Q19/00 A61Q5/00 A61Q5/12 A61Q11/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to novel arylsulphonamide-substituted hydroxamic acid derivatives of formula (I) , where R₁ is a C₁-C₇alkyl group substituted with at least two OH groups or one X-monosaccharide, where X is an O atom, R₂ is selected from a group consisting of H, C₁-C₇alkyl substituted with one hydroxyl group, R₃ is selected from a group consisting of oxy- C₁-C₇alkyl, phenyl, and to pharmaceutically acceptable salts thereof, having good solubility and selective inhibiting effect on matrix metalloproteinase MMP-12, MMP-8, MMP-13, MMP-1, to pharmaceutical compositions and cosmetic agents based on said compounds, as well as to methods of inhibiting MMP-12, MMP-8, MMP-13, MMP-1.

EFFECT: obtaining novel arylsulphonamide-substituted hydroxamic acid derivatives.

13 cl, 4 tbl, 8 ex