FIELD: chemistry.
SUBSTANCE: invention relates to organic chemistry and a method of producing N-(β-hydroxyethyl)-4,6-dimethyldihydropyrimidone-2, known in medicine as Xymedon, involving recrystallisation of hydrochloride, N-(β-hydroxyethyl)-4,6-dimethyldihydropyrimidone-2 from ethanol and then treated with a sodium hydroxide solution in ethanol. The sodium chloride formed is removed by filtering. Crude N-(β-hydroxyethyl)-4,6-dimethyldihydropyrimidone-2 is separated by evaporating ethanol and purified by double recrystallisation from chemically pure isopropyl alcohol in the presence of aluminium oxide and activated carbon.
EFFECT: method enables to obtain a highly pure product.
3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PROCESS FOR PREPARING N-(β-HYDROXYETHYL)-4,6-DIMETHYLDIHYDROPYRIMIDON-2 | 1992 |
|
RU2044730C1 |
| 0 |
|
SU460628A3 | |
| METHOD OF PREPARING GLYCOSIDE ELICITING CARDIOTONIC EFFECT | 1999 |
|
RU2196600C2 |
| 0 |
|
SU349177A1 | |
| METHOD OF PREPARING 2-TETRAHYDROFURIL-6,7-BENZOMORPHANES OR SALTS THEREOF | 0 |
|
SU588916A3 |
| METHOD OF SYNTHESIS OF BENZHYDROL β-DIMETHYLAMINOETHYL ESTER HYDROCHLORIDE | 1992 |
|
RU2036899C1 |
| METHOD OF OBTAINING PIPERIDINE DERIVATIVES | 0 |
|
SU649321A3 |
| PIPERAZINE DERIVATIVES | 1994 |
|
RU2124511C1 |
| PROCESS FOR PREPARING DERIVATIVES OF STEROIDOSPIROOXATHIAZOLIDINES IN THE FORM OF THEIR STEREOISOMERS,OR THEIR MIXTURES,OR THEIR SALTS | 0 |
|
SU1079177A3 |
