PIPERAZINE DERIVATIVES Russian patent published in 1999 - IPC

FIELD: organic chemistry. SUBSTANCE: invention relates to derivatives of piperazine of the formula (I) where Q - phenyl, naphthyl, pyridyl, pyrimidyl, furyl, isoquinolinyl, benzofuranyl, dihydrobenzofuranyl, benzyl, diphenylmethyl possibly substituted with 1 or more substituents taken from alkyl, alkoxyl, trifluoromethyl, dialkylamino, halogen, cyano- and ethylenedihydroxy-group; R - groups of the formula (a) and (b) where R¹ and R² are C_1-6-alkoxyl or methylenedihydroxy-group; G is C_3-6-cycloalkyl, phenyl, benzoyl, benzylcarbonyl, alpha-hydroxybenzyl, pyrrolyl where nitrogen atom has hydrogen atom or alkyl or takes part in binding with R, alkyl group substituted with heterocyclic group (thienyl, imidazolyl); alkanoylamino-group, morpholinoalkyl, 1-alkylindole-2-yl-group, phenylalkyl. Compounds of the formula (I) can be used as a drugs at different diseases of circulation organs or cerebral region, in part, that's caused by an excessive activation of calmodulin. EFFECT: improved method of synthesis, enhanced effectiveness of compounds. 13 cl, 6 tbl, 123 ex