IMIDAZO[1,2-a]PYRIDINE DERIVATIVES USED AS PEPTIDE DEFORMYLASE INHIBITORS Russian patent published in 2011 - IPC C07D471/04 A61K31/04 A61K31/437 A61P31/00 

FIELD: chemistry.

SUBSTANCE: invention relates to imidazo[1,2-a]pyridine derivatives of formula in which radicals R¹, R², R³ and R⁴ independently denote a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a nitro group, a (C₁-C₁₂)alkyl radical which can be substituted with one or more halogen atoms or OH, and a O-(C₁-C₁₂)alkyl radicalwhich is substituted with phenyl, or two of radicals R¹, R², R³ and R⁴ can denote part of a phenyl ring; R⁵ denotes a (C₁-C₁₂)alkyl radical which can be substituted with one or more OH, methanesulphanyl, COOH or a halogen atom, (C₂-C₁₂)alkenyl radical, (C₂-C₁₂)alkynyl radical, (C₆-C₁₀)aryl radical, heteroaryl radical, which is an aromatic groupcontaining 5-10 ring members and 1-2 nitrogen or oxygen ring atoms, (C₃-C₁₀)cycloalkyl radical, (C₁-C₁₂)alkyl(C₃-C₁₀)cycloalkyl radical, (C₆-C₁₀)aryl(C₁-C₁₂)alkyl radical; radicals R⁶ and R⁷ independently denote a hydrogen atom or a (C₁-C₁₂)alkyl radical, which can be substituted with COOH, (C₆-C₁₀)aryl radical; and X denotes a group of formula - CO-NHOH or formula where U denotes a bond, CH₂, V denotes O, S, W denotes NH, and Y denotes OH, or pharmaceutically acceptable salts thereof, solvates, hydrates. The invention also relates to the pharmaceutical composition based on the formula I compound and use of the formula I compound.

EFFECT: novel derivatives have peptide deformylase inhibiting activity.

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