FIELD: chemistry.
SUBSTANCE: invention relates to imidazo[1,2-a]pyridine derivatives of formula in which radicals R1, R2, R3 and R4 independently denote a hydrogen atom, a halogen atom, a hydroxyl group, an amino group, a nitro group, a (C1-C12)alkyl radical which can be substituted with one or more halogen atoms or OH, and a O-(C1-C12)alkyl radicalwhich is substituted with phenyl, or two of radicals R1, R2, R3 and R4 can denote part of a phenyl ring; R5 denotes a (C1-C12)alkyl radical which can be substituted with one or more OH, methanesulphanyl, COOH or a halogen atom, (C2-C12)alkenyl radical, (C2-C12)alkynyl radical, (C6-C10)aryl radical, heteroaryl radical, which is an aromatic groupcontaining 5-10 ring members and 1-2 nitrogen or oxygen ring atoms, (C3-C10)cycloalkyl radical, (C1-C12)alkyl(C3-C10)cycloalkyl radical, (C6-C10)aryl(C1-C12)alkyl radical; radicals R6 and R7 independently denote a hydrogen atom or a (C1-C12)alkyl radical, which can be substituted with COOH, (C6-C10)aryl radical; and X denotes a group of formula - CO-NHOH or formula where U denotes a bond, CH2, V denotes O, S, W denotes NH, and Y denotes OH, or pharmaceutically acceptable salts thereof, solvates, hydrates. The invention also relates to the pharmaceutical composition based on the formula I compound and use of the formula I compound.
EFFECT: novel derivatives have peptide deformylase inhibiting activity.
16 cl
Title | Year | Author | Number |
---|---|---|---|
IMIDAZO[1,2,-a]PYRIDINE DERIVATIVES TO BE USED AS PEPTIDE DEFORMYLASE (PDF) INHIBITORS | 2006 |
|
RU2420526C2 |
BICYCLIC DERIVATIVES OF IMIDAZO-3-YLAMINE, METHOD FOR THEIR PREPARING AND MEDICINAL AGENT BASED ON THEREOF | 2000 |
|
RU2264402C2 |
SUBSTITUTED BICYCLIC IMDAZO-3-YLAMINES SUITABLE FOR REGULARING mGluR5-RECEPTOR | 2005 |
|
RU2435770C2 |
ARYL-ISOXAZOL-4-YL-IMIDAZO[1,2-a]PYRIDINE SUITABLE FOR TREATING ALZHEIMER'S DISEASE THROUGH GABA RECEPTORS | 2007 |
|
RU2426732C2 |
DERIVATIVE OF PYRIMIDINE AND A FIVE-MEMBERED NITROGEN-CONTAINING HETEROCYCLE, METHOD FOR PRODUCTION AND MEDICAL APPLICATIONS THEREOF | 2019 |
|
RU2775229C1 |
METHODS AND COMPOSITIONS TO IMPROVE COGNITIVE FUNCTIONS | 2012 |
|
RU2792010C2 |
METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTIONS | 2012 |
|
RU2665021C2 |
ACETYLENYL-PYRAZOLE-PYRIMIDINE DERIVATIVES AS mGluR2 ANTAGONISTS | 2006 |
|
RU2412943C2 |
8-METHYL-1-PHENYLIMIDAZO[1,5-a]PYRAZINE COMPOUNDS | 2011 |
|
RU2560162C2 |
COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY | 2014 |
|
RU2673542C2 |
Authors
Dates
2011-01-20—Published
2006-04-24—Filed