COMPOUNDS FOR TREATING SPINAL MUSCULAR ATROPHY Russian patent published in 2018 - IPC C07D471/04 C07D413/12 C07D413/14 A61K31/4985 A61K31/437 A61K31/496 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to compounds of formula (I) wherein X is N or CR³; Y is N or CR⁴; provided that both X and Y are not N; A is selected from the group of imidazo[1,2-a]pyrazin-2-yl, imidazo[1,2-a]pyridinyl and benzo[d]oxazolyl which are optionally substituted with one, two or three R⁵; B is 1,2,3,6-tetrahydropyridinyl, 2,6-diazaspiro[3.3]heptanyl, hexahydro-pyrrolo[3,4-c]pyrrolyl, hexahydro-pyrrolo[1,2-a]pyrazinyl, piperazinyl or piperidinyl, each optionally substituted with one, two or three R⁶; R¹ is hydrogen, halogen, C_1-7-alkoxy or C_1-7-haloalkoxy; R² is hydrogen, halogen or C_1-7-alkyl; R³ is hydrogen or halogen; R⁴ is hydrogen, halogen, C_1-7-alkoxy or C_1-7-haloalkoxy; each R⁵ is independently selected from halogen, C_1-7-alkyl or C_1-7-haloalkyl; each R⁶ is C_1-7-alkyl; or to pharmaceutically acceptable salts thereof. Invention also relates to pharmaceutical compositions having the activity of a SMN2 gene splicing modulator based on said compounds.

(I).

EFFECT: technical result is obtaining new compounds and pharmaceutical compositions based on thereon, which can be used in medicine for the production of medicaments.

25 cl, 4 tbl, 82 ex