FIELD: medicine.
SUBSTANCE: invention refers to oligonucleotide with the sequence SEQ ID NO: 1 or to its functional homolog (nucleotide sequence is disclosed in the description). Oligonucleotide is used to induce apoptosis of neoplastic B-cells and to treat B-lymphoid neoplasm in a subject mammal. According to the invention, oligonucleotide is used as an ingredient of a pharmaceutical composition for treating B-lymphoid neoplasm in the subject mammal in a combination with a B-lymphoid neoplasm drug specified among chemotherapeutic drugs, immunotherapeutic drugs, particularly CD20 antibody, or drugs used in radiation therapy.
EFFECT: oligonucleotide under the invention induces apoptosis of neoplastic B-cells, increases CD40 expression on neoplastic B-cells and stimulates IL-10 formation.
17 cl, 7 dwg, 2 tbl, 9 ex
