OLIGONUCLEOTIDES OR THEIR FUNCTIONAL HOMOLOGUES, COMPOSITION CONTAINING THEM AND METHOD OF TREATING B-CELL TUMOUR Russian patent published in 2011 - IPC A61K31/7088 A61K31/573 A61P35/00 A61P35/02 

FIELD: medicine.

SUBSTANCE: declared group of inventions refers to medicine, namely to oncology, and can be used for treating B-cell tumour in a mammal. The method of treating B-cell tumour consists in administering a therapeutically effective amount of a pharmaceutical composition containing oligonucleotide having any of sequences SEQ ID NO: 1-9. Also, there are offered a method for inducing cell apoptosis of B-cell tumour, a method for increasing CD40 cell expression of B-cell tumour, and a method for inducing IL-10 cell production of B-cell tumour by contacting said cells of B-cell tumour with the composition containing oligonucleotide having any of sequences SEQ ID NO: 1-9. Besides, offered is the pharmaceutical composition containing (1) oligonucleotide having any of sequences SEQ ID NO: 1-9, and (2) a B-cell tumour agent.

EFFECT: invention provides effective therapy of B-cell tumour due to inducing tumour cell apoptosis which is caused by increasing CD40 cell expression of B-cell tumour and stimulated IL-10 cell production of B-cell tumour.

21 cl, 3 dwg, 5 tbl, 9 ex