NAPHTHYRIDINE DERIVATIVES Russian patent published in 2011 - IPC C07D471/04 A61K31/435 A61P25/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to heterocyclic derivatives of general formula (I) where R¹ denotes hydrogen, halogen, cyano, lower alkoxy or lower alkyl; R² denotes aryl or a 5- or 6-member heteroaryl; R³ denotes hydrogen, aryl, a 5- or 6-member heteroaryl, where aryl, cycloalkyl, heterocycloalkyl or 5- or 6-member heteroaryl groups for R² and R³ may be unsubstituted or substituted with halogen, cyano, lower alkyl, possibly substituted with one or more halogens, lower alkoxy, S(O)₂-alkyl, -C(O)R', where R' is a lower alkyl, lower alkoxy; as well as pharmaceutically acceptable salts thereof. The invention also relates to a medicine based on said compounds for treating and preventing diseases mediated by the mGIuR5 receptor and use of compounds of formula (I) in preparing medicines.

EFFECT: novel compounds which are metabotropic glutamate receptor antagonists are obtained and described.

17 cl, 81 ex