FIELD: chemistry.
SUBSTANCE: present invention relates to heterocyclic derivatives of general formula (I) where R1 denotes hydrogen, halogen, cyano, lower alkoxy or lower alkyl; R2 denotes aryl or a 5- or 6-member heteroaryl; R3 denotes hydrogen, aryl, a 5- or 6-member heteroaryl, where aryl, cycloalkyl, heterocycloalkyl or 5- or 6-member heteroaryl groups for R2 and R3 may be unsubstituted or substituted with halogen, cyano, lower alkyl, possibly substituted with one or more halogens, lower alkoxy, S(O)2-alkyl, -C(O)R', where R' is a lower alkyl, lower alkoxy; as well as pharmaceutically acceptable salts thereof. The invention also relates to a medicine based on said compounds for treating and preventing diseases mediated by the mGIuR5 receptor and use of compounds of formula (I) in preparing medicines.
EFFECT: novel compounds which are metabotropic glutamate receptor antagonists are obtained and described.
17 cl, 81 ex
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Authors
Dates
2011-05-20—Published
2006-09-25—Filed