FIELD: chemistry.
SUBSTANCE: invention relates to analogues of benzoquinone-containing ansamycins of formulae
and ,
in which radicals and symbols assume values given in the claim, and use thereof to treat and modulate proliferation-associated disorders such as cancer. The present invention describes a method of producing analogues of benzoquinone-containing ansamycins according to which benzoquinone is reduced to hydroquinone and bonded through reaction with a suitable acid.
EFFECT: high solubility and air stability of the obtained ammonium hydroquinone ansamycin analogue.
181 cl, 70 dwg, 38 ex
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Authors
Dates
2013-06-10—Published
2004-12-23—Filed