ANALOGUES OF BENZOQUINONE-CONTAINING ANSAMYCINS (VERSIONS), METHOD FOR PRODUCTION THEREOF, PHARMACEUTICAL COMPOSITION (VERSIONS) AND CANCER TREATMENT METHOD (VERSIONS) Russian patent published in 2013 - IPC C07D225/06 C07D498/06 C07D211/60 C07F5/02 A61K31/395 A61P35/00 

Abstract RU 2484086 C9

FIELD: chemistry.

SUBSTANCE: invention relates to analogues of benzoquinone-containing ansamycins of formulae

and ,

in which radicals and symbols assume values given in the claim, and use thereof to treat and modulate proliferation-associated disorders such as cancer. The present invention describes a method of producing analogues of benzoquinone-containing ansamycins according to which benzoquinone is reduced to hydroquinone and bonded through reaction with a suitable acid.

EFFECT: high solubility and air stability of the obtained ammonium hydroquinone ansamycin analogue.

181 cl, 70 dwg, 38 ex

Similar patents RU2484086C9

Title Year Author Number
COMPOUNDS AND METHODS OF INHIBITING INTERACTION OF BCL PROTEINS WITH BINDING COMPONENTS 2006
  • Kastro Al'Fredo S.
  • Grogan Majkl Dzh.
  • Kholson Ehduard B.
  • Khopkins Brajan T.
  • Kouni Naj O.
  • Peljuzo Stefan
  • Snajder Daniel A.
RU2424230C2
SUBSTITUTED BICYCLIC COMPOUNDS, PARENT AND INTERMEDIATE SUBSTANCES FOR THEIR SYNTHESIS AND PHARMACEUTICAL COMPOSITION BASED ON THEREOF 1998
  • Mittendorf Joakhim
  • Dressel' Jurgen
  • Mattske Mikhael'
  • Kel'Denikh Jerg
  • Mors Klaus-Khel'Mut
  • Raddatts Zigfrid
  • Frants Jurgen
  • Shprajer Peter
  • Feringer Ferena
  • Shumakher Joakhim
  • Rok Mikhael'-Kharol'D
  • Khorvat Ehrvin
  • Fridl' Arno
  • Mauler Frank
  • De Vrij Zhan-Mari-Viktor
  • Jork Rajnkhard
RU2203272C2
CYCLOPAMINE ANALOGUES AND METHODS OF THEIR APPLICATION 2005
  • Dzhanardanannair Somaradzhannair
  • Adams Dzhulian
  • Tremblehj Martin
  • Kastro Al'Fredo S.
  • Fouli Majkl A.
  • Nevalainen Marta
  • Porter Dzhejms R.
RU2403256C2
SUBSTITUTED BICYCLIC COMPOUNDS, PHARMACEUTICAL COMPOSITION BASED ON THEREOF AND METHOD OF INHIBITION 1998
  • Chakalamannil Sehmjuehl
  • Asberom Teodros
  • Ksia Jen
  • Doller Dario
  • Klasbi Martin
  • Kzarnieki Majkl F.
RU2204557C2
PIPERIDINYLPIPERAZINE DERIVATIVES APPLICABLE AS CHEMOKINE RECEPTOR INHIBITORS 2006
  • Chan Tze-Ming
  • Koks Kehtlin
  • Feng Venking
  • Miller Majkl V.
  • Uehston Dehniehl
  • Makkombi Stjuart V.
RU2411241C2
BENZOTHIEPINES, PHARMACEUTICAL COMPOSITION BASED ON THEREOF, METHOD OF PROPHYLAXIS AND TREATMENT OF HYPERLIPIDEMIC STATE 1997
  • Rejts Dehvid B.
  • Li Len F.
  • Li Dzhinglin Dzh.
  • Khuang Khorng-Chin
  • Tremont Samuehl' Dzh.
  • Miller Rehjmond E.
  • Banerdzhi Shamal S.
RU2202549C2
ARYL, HETEROARYL AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS 2018
  • Uajls, Dzhejson, Allan
  • Fadke, Avinash, S.
  • Deshpande, Milind
  • Agarval, Atul
  • Chen, Davej
  • Gadkhachanda, Venkat, Rao
  • Khashimoto, Akikhiro
  • Pejs, Godvin
  • Van, Tsyupin
  • Van, Syanchzhu
  • Berrish, Dzhoel, Charlz
  • Grinli, Uillyam
  • Istman, Kajl, Dzh.
RU2801278C2
COMPOUNDS AND METHODS OF INHIBITING INTERACTION OF BCL PROTEINS WITH BINDING COMPONENTS 2005
  • Kastro Al'Fredo S.
  • Dehn Vehj
  • Dip'Ju Kristofer M.
  • Foli Majkl A.
  • Fritts Kristian S.
  • Kheorkhes-Ehvankhelinos Asimina T.
  • Grogan Majkl Dzh.
  • Khafees Nafeesa
  • Kholson Ehduard B.
  • Khopkins Brajan T.
  • Koni Nil O.
  • Lju Tao
  • Mann Dejvid A.
  • Markaorelle Lajza A.
  • Snajder Daniel A.
  • Andervud Dennis Dzh.
  • Uajli Ehndr'Ju A.
  • Ju Lin'Chen'
  • Chzhan Lipin
RU2416606C2
DERIVATIVES SHOWING PPAR-RECEPTOR AGONIST ACTIVITY 2006
  • Itai Akiko
  • Muto Suzumu
  • Tokujama R'Juko
  • Fukusava Khiroshi
  • Okhara Takafumi
  • Kato Terukazu
  • Takajama Khirotsugu
RU2415846C2
DERIVATIVES OF FIVE-MEMBER HETEROCYCLES, METHOD OF PRODUCTION AND USE THEREOF AS MEDICINAL AGENTS 2000
  • Shabrie De Lasson'Er P'Er-Eht'Enn
  • Kharnett Dzheremia
  • Bigg Denni
  • Pomm'E Zhak
  • Lannua Zhak
  • Liberator Ann-Mari
  • Tjur'O Kristof
RU2380362C2

RU 2 484 086 C9

Authors

Adams Dzhulian

Gao Jun'

Georges Ehvangelinos Asimina T.

Gren'E Lui

Porter Dzhejms R.

Pehk Rodzher Kh.

Rajt Dzhejms L.

Dates

2013-06-10Published

2004-12-23Filed