FIELD: medicine.
SUBSTANCE: invention refers to a method for preparing a phospholipid nanoparticle enclosed chlorine E6 therapeutic agent applicable as a remedy for photodynamic therapy. An aqueous solution of maltose prepared by heating is mixed with chlorine E6 and then mixed with an aqueous emulsion of phosphatidylcholine. The prepared emulsion is subject to several homogenisation cycles under high pressure of 500-1,000 atm at a temperature of 40-50°C followed by neutralising in alkaline water and lyophilising.
EFFECT: more effective application of the compound.
1 tbl, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD FOR PRODUCING COMPOSITION FOR PHOTODYNAMIC THERAPY IN FORM OF PHOSPHOLIPID NANOPARTICLES BASED ON GLUCAMINE CHLORINE E6 SALT, MALTOSE AND PHOSPHATIDYLCHOLINE | 2014 |
|
RU2576025C1 |
| MEDICATION FOR PHOTODYNAMIC THERAPY, METHOD OF OBTAINING CLAIMED MEDICATION AND METHOD OF CARRYING OUT PHOTODYNAMIC THERAPY WITH APPLICATION OF CLAIMED MEDICATION | 2010 |
|
RU2428981C1 |
| PHARMACEUTICAL COMPOSITION CONTAINING CHLORIN E6 IN PHOSPHOLIPID NANOPARTICLES USING SPECIFIC AND PENETRATING PEPTIDES AS TARGETED MOLECULES FOR TARGETED TRANSPORT | 2020 |
|
RU2747485C1 |
| PHOTOSENSITISER AND METHOD FOR PREPARING THEREOF | 2008 |
|
RU2367434C1 |
| PHOTOSENSITISER AND METHOD OF ITS OBTAINING | 2013 |
|
RU2523380C1 |
| PHOTOSENSIBILIZER AGENT AND METHOD FOR PRODUCING IT | 2001 |
|
RU2183956C1 |
| METHOD FOR PHOTODYNAMIC THERAPY | 2015 |
|
RU2637279C2 |
| PHOTOSENSITIZER BASED ON THE COMPLEX OF CHLORIN E6 AND EUROPIUM | 2022 |
|
RU2797948C1 |
| METHOD OF PHOTODYNAMIC THERAPY OF SUBJECTS WITH MALIGNANT TUMOURS | 2010 |
|
RU2440158C2 |
| METHOD FOR PHOTODYNAMIC THERAPY OF LEFT TUMORS OF MICE EHRLICH CARCINOMA WITH CHLORINE SERIES PHOTO-SENSITIZER | 2022 |
|
RU2788766C2 |
