FIELD: chemistry.
SUBSTANCE: described is an improved method for synthesis of 3(5)-pyridyl-substituted 5(3)-amino-1,2,4-triazoles of general formula (I)
, where R denotes 2-pyridyl, 3-pyridyl or 4-pyridyl, involving reaction of pyridine carboxylic acid of general formula (II)
, where R assumes said values, with an aminoguanidine hydrocarbonate in the presence of hydrochloric acid in molar ratio acid (II): aminoguanidine hydrocarbonate: hydrochloric acid = 1.0:1.0:1.3-1.5, while boiling the reaction mixture with gradual distillation of water at atmospheric pressure until temperature of the reaction mixture equals 165-180°C and then holding the reaction mixture at this temperature for 3-5 hours and then adding an alkali solution in water, boiling alkaline solution and extraction of the end product by filtering after neutralisation of the reaction mixture and cooling.
EFFECT: method enables to obtain said compounds from cheaper material, increases output of end products and shortens duration of the synthesis process.
1 cl, 14 ex
| Title | Year | Author | Number |
|---|---|---|---|
| METHOD OF PRODUCING 5-AMINO-3-AMINOMETHYL-1,2,4-TRIAZOLE DIHYDROCHLORIDE | 2011 |
|
RU2476428C1 |
| PROCESS FOR PRODUCING 3-AMINO-5-METHYLMERCAPTO-1,2,4-TRIAZOLE | 0 |
|
SU1002291A1 |
| METHOD FOR PREPARING 5-AMINO-1,2,4-TRIAZOLE-3-YLACETIC ACID MONOHYDRATE | 2006 |
|
RU2313522C1 |
| METHOD OF PREPARING 3-AMINO-5-(2-AMINOETHYL)-1,2,4-TRIAZOLE | 0 |
|
SU557574A1 |
| 0 |
|
SU320496A1 | |
| METHOD FOR PRODUCTION OF 5-AMINO-1,2,4-TRIASOL-3-YLCARBOXYLIC ACID OR 5-AMINO-1,2,4-TRIASOL-3-YLACETIC ACID ESTERS | 2004 |
|
RU2269521C1 |
| 0 |
|
SU176913A1 | |
| 0 |
|
SU306128A1 | |
| METHOD OF PRODUCING 5-SUBSTITUTED 1,2,4-TRIAZOLE-3-CARBOXYLIC ACIDS AND DERIVATIVES THEREOF FROM UNIVERSAL PRECURSOR | 2015 |
|
RU2605414C1 |
| PROCESS FOR PREPARATION OF 4-[5-(PYRIDIN-4-YL)-1H-1,2,4-TRIAZOL-3-YL]PYRIDINE-2-CARBONITRILE AND ITS INTERMEDIATE | 2013 |
|
RU2644766C2 |
