FIELD: organic chemistry, chemical technology.
SUBSTANCE: invention describes a method for synthesis of 5-amino-1,2,4-triazole-3-ylacetic acid. Method involves interaction of malonic acid with aminoguanidine hydrocarbonate in the ratio = 1.1:(1.0-1.3) at pH 0-1 in the presence of HCl. Then water is distilled off from the reaction mixture under vacuum followed by cyclization of formed malonic acid monoguanylhydrazide by effect with alkali and isolation of the end substance at acidification of the reaction mass to pH 3-4 and cooling. All process is carried out at temperature 80-1000C. Proposed process provides preparing the end substance with high yield for short period of time.
EFFECT: improved method of synthesis.
2 cl, 1 dwg, 8 ex
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