FIELD: chemistry.
SUBSTANCE: described is an improved method of producing 5-amino-3-aminomethyl-1,2,4-triazole dihydrochloride, which can be used in producing medicinal and biologically active substances and chemicals. The described method involves successively mixing aminoguanidine bicarbonate, hydrochloric acid and phthalimidoglycine of formula (II) in molar ratio 1.0:(1.0÷1.1):1.0 and the obtained mixture is heated with gradual distillation of water at atmospheric pressure and stirring until achieving temperature of 160-185°C; the reaction mixture is then heated at that temperature for 1-5 hours, after which a solution of sodium carbonate in water is added until achieving pH 10-11; the obtained solution is boiled and the compound of formula (III) formed is separated and subjected to hydrolysis with hydrochloric acid.
EFFECT: improved method of producing 5-amino-3-aminomethyl-1,2,4-triazole dihydrochloride.
1 cl, 6 ex
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Authors
Dates
2013-02-27—Published
2011-09-01—Filed