PYRAZOLEPYRIMIDINES Russian patent published in 2011 - IPC C07D487/04 A61K31/519 A61P35/00 

FIELD: chemistry.

SUBSTANCE: compounds can be used to treat tumourous diseases, such as solid tumours, breast, lung, large intestine or prostate gland tumours. In compounds of formula

: R¹ is selected from a group comprising: (a) saturated cyclic radical containing 3-8 ring atoms, from which 1-3 atoms are N atoms, which can contain up to four substitutes independently selected from a group comprising: (i) lower alkyl; and (ii) CO₂R³, OR⁷ or S(O)_nR⁸; (b) C₆-C₁₀aryl, which can contain up to four substitutes independently selected from a group comprising: (i) S(O)_nR⁸, lower alkyl; OR⁷ and halogen; (c) C₃-C₈cycloalkyl, which can be substituted with NR⁵R⁶; and (d) lower alkyl, which can be substituted: (i) OR⁷, NR⁵R⁶; R² is selected from a group comprising: (i) H; (ii) lower alkyl; (iii) C₆-C₁₀aryl which can be substituted with a halogen, lower alkyl, lower alkoxy group; R³ is selected from a group comprising: (i) H; (ii) lower alkyl; (iv) C₃-C₈cycloalkyl; R⁵ and R⁶ are independently selected from a group comprising: (i) H; (ii) lower alkyl; (iii) C₃-C₈cycloalkyl; (v) SO₂R³; and (vi) CO₂R³; R⁷ is selected from a group comprising H and lower alkyl; R⁸ is selected from a group comprising: (iii) NR⁵R⁶; (iv) lower alkyl; and n equals 1 or 2.

EFFECT: capacity to inhibit activity of cyclin-dependant kinase.