FIELD: chemistry.
SUBSTANCE: present invention relates to a method of producing (R)-(-)-sertaconazole mononitrate, in which first, a chemical reaction takes place between (R)-(-)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)-ethanol 
and an intermediate of general formula 
where L denotes a leaving group, in the presence of an interphase catalyst and a base in a medium consisting of water and a water-immiscible solvent; followed by treatment with nitric acid and recrystallisation of the solid product formed from a suitable solvent which contains a mixture of an alcohol containing 1-4 carbon atoms and acetone; the formed polyacetone of R-(-)-sertaconazole mononitrate is converted to R-(-)-sertaconazole mononitrate 
by drying at temperature between 80 and 90°C; and the obtained R-(-)-sertaconazole mononitrate (V) is purified. The invention also relates to polyacetonate of R-(-)-sertaconazole mononitrate 
.
EFFECT: novel interphase process of producing R-(-)-sertaconazole mononitrate (V).
24 cl, 1 dwg, 1 tbl, 2 ex
| Title |
Year |
Author |
Number |
| SERTACONASOLE MONONITRATE PROCESS AND SERTACONASOLE MONONITRATE MONOHYDRATE |
2005 |
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|
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|
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2019 |
- Popkov Sergej Vladimirovich
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- Alekseenko Anna Leonidovna
|
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- Popkov Sergej Vladimirovich
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|
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2000 |
- Sato Koudzi
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- Okano Katsukhiko
- Nakajama Keidzi
- Imura Akikhiro
- Itokh Mikikhiro
- Jagi Tsutomu
- Kobajasi Jukinari
- Nagai Tomojuki
|
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2019 |
|
RU2805659C2 |
| SUBSTITUTED O-[ω-(AZOL-1-YL)ALKYL]-N-PHENYLTHIOCARBAMATES, METHOD OF OBTAINMENT, FUNGICIDE COMPOSITION BASED ON THEM |
2007 |
- Popkov Sergej Vladimirovich
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|
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| METHOD FOR PRODUCING (5S)-4-[5-(3,5-DICHLOROPHENYL)-5-(TRIFLUOROMETHYL)-4H-ISOXAZOL-3-YL]-2-METHYLBENZOIC ACID |
2019 |
|
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| METHOD OF PRODUCING LAKOSAMIDE |
2010 |
- Bologna Alberto
- Castoldi Patrizia
- Vergani Domenico
- Bertolini Giorgio
|
RU2585762C2 |
| METHOD OF SYNTHESIS OF AROMATIC DERIVATIVES OR THEIR SALTS WITH ORGANIC OR INORGANIC ACIDS OR THEIR RACEMATES |
1990 |
- Ksav'E Ehmon-Al'T[Fr]
- P'Er Guljauik[Fr]
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