MEDICATION POSSESSING IMMUNOSTIMULATING AND HEMOSTIMULATING ACTION Russian patent published in 2011 - IPC A61K31/7088 A61K45/08 B82B3/00 A61P7/06 A61P37/04 

FIELD: medicine, pharmaceutics.

SUBSTANCE: claimed is application of immobilised oligonucleotides as immunostimulating and hemostimulating medication for peroral introduction. Immobilised on polyethylene oxide oligonucleotides of DNA of salmon soft roes demonstrate immuno- and hemostimulating activity in conditions in vivo in case of peroral introduction in experimental animals and in vitro, which is manifested in stimulation of phagocytic reactions in vivo and in vitro, increase of IFN-γ in vitro, increase of cytotoxic activity of natural killers, increase of spontaneous proliferative activity of lymphoid cells of experimental animals and index of B-lymphocyte stimulation, increase of nitrogen oxide production, as well as in enchancement of hemopoiesis regeneration in early terms after cytostatic impact.

EFFECT: immobilised by physical method oligonucleotides are protected from destruction in gastrointestinal tract, which facilitates their permeability through intestine wall and increases bioavailability.

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