NOVEL OXAZOLIDINONE DERIVATIVES Russian patent published in 2011 - IPC C07D413/14 A61K31/422 A61P31/04 C07D417/14 C07D417/10 C07D413/10 A61K31/427 

FIELD: chemistry.

SUBSTANCE: invention relates to oxazolidinone derivatives of formula (I) or pharmaceutically acceptable salts thereof, synthesis method thereof and pharmaceutical compositions containing said derivatives which are used as an antibiotic. Oxazolidinone derivatives, where R₁ and R₁' independently denote hydrogen or fluorine; R₂ denotes -OR₇, fluorine, monophosphate or metal phosphate; and R₇ denotes hydrogen, C_1-3alkyl or an acylated amino acid group, where the amino acid is alanine, glycine, proline, proline, isoleucine, leucine, phenylalanine, β-alanine or valine; R₃ denotes hydrogen, a C_1-4alkyl group which is unsubstituted or substituted cyano, , -(CH₂)_m-OR₇ (m equals 0, 1, 2, 3, 4) or a ketone group. Oxazolidinone derivatives of formula (I) have antibacterial activity against different human and animal pathogens.

EFFECT: oxazolidinone derivatives, having inhibiting activity towards a wide range of bacteria and having low toxicity.

27 cl, 4 tbl, 73 ex