CRYSTALLINE FORMS OF THIAZOLIDINEDIONE COMPOUNDS AND SYNTHESIS METHOD THEREOF Russian patent published in 2011 - IPC C07D417/12 A61K31/427 A61P35/00 

Abstract RU 2414470 C2

FIELD: chemistry.

SUBSTANCE: invention relates to crystalline forms of a hydrate of 5-(4-{[6-(4-amino-3,5-dimethylphenoxy)-1-methyl-1-H-benzimidazol-2-yl]methoxy}benzyl)-1,3-thiazolidine-2,4-dione dihydrochloride of formula (I). The invention also relates to methods for synthesis of said compounds and to pharmaceutical compositions based on said compounds, having PPARy activating property.

EFFECT: said forms of the compounds are more stable and can be used in medicine to prepare medicinal agents for treating diabetes, cancer accompanied by diabetes.

16 cl, 7 tbl, 5 dwg, 6 ex

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Authors

Kadzino Khisaki

Ikeuti Jutaka

Mijamoto Khirosi

Numagami Eidzi

Nikhei Satoru

Dates

2011-03-20Published

2008-02-08Filed