BENZIMIDAZOLE DERIVATIVES, BASED PHARMACEUTICAL COMPOSITION AND METHODS OF USING THEM Russian patent published in 2012 - IPC C07D235/12 C07D405/12 C07D471/04 A61K31/4184 A61P1/04 A61P1/16 A61P1/18 A61P3/04 A61P3/06 A61P3/10 A61P7/00 A61P7/10 A61P9/00 A61P9/10 A61P9/12 A61P11/06 A61P17/04 A61P17/06 A61P17/10 A61P17/16 A61P19/10 A61P25/28 A61P27/02 A61P27/14 A61P29/00 A61P35/00 A61P43/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: present invention refers to new benzimidazole derivatives of general formula (I) or to its pharmacologically acceptable salts wherein R¹ represents a C₆-aryl group which can be substituted by 1-3 groups optionally specified in a group of substitutes (a), or a heterocyclic group which represents pyridyl, dihydrobenzofuranyl, 1,3-benzodioxolyl, tetrahydropyranyl, tetrahydrofuranyl which can be substituted by 1-3 groups optionally specified in a group of substitutes (a), R² represents a C₁-C₆ alkyl group, R³ represents a C₆-aryl group which can be substituted by 1-2 groups optionally specified in a group of substitutes (a), Q represents a group represented by formula =CH-, or a nitrogen atom and a group of substitutes (a) represents a group consisting of a halogen atom, a C₁-C₆ alkyl group, a C₁-C₆ halogenated alkyl group, a carboxyl group, a C₂-C₇ alkylcarbonyl group, a C₂-C₇ alkoxycarbonyl group, a C₁-C₆ alkoxy group, a C₁-C₆ halogenated alkoxy group, an amino group, a 4-morpholinyl group and a di-C₁-C₆ alkyl)amino group. Also, the invention refers to a pharmaceutical composition based on a compound of formula (I), to a PPARγ activator/modulator based on the compound of formula (I), to using the compound of formula (I), to a method of reducing blood glucose, to a method of activating PPARγ, a method of treating and/or preventing said pathological conditions.

EFFECT: there are produced new benzimidazole derivatives showing PPARγ modulatory activity.

41 cl, 2 dwg, 6 tbl, 76 ex