CARBOSTYRIL COMPOUND Russian patent published in 2011 - IPC C07D417/06 C07D417/04 C07D417/14 A61K31/4709 A61K31/4725 A61K31/473 A61K31/496 A61K31/497 A61K31/5377 A61K31/541 A61K31/55 A61P1/00 A61P1/02 A61P1/04 A61P11/00 A61P11/06 A61P17/02 A61P17/16 A61P27/02 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel carbostyril compounds of general formula (1) or salts thereof with common pharmaceutically acceptable acids or pharmaceutically acceptable basic compounds, having activity on promotion of TFF2 production, a pharmaceutical composition based on said compounds, an agent based on disclosed compounds used in case of a disorder where up-regulation of TFF has a prophylactic and/or therapeutic effect, use of disclosed compounds to prepare said agent and a method of producing disclosed compounds. The invention also relates to novel specific carbostyril compounds or salts thereof with common pharmaceutically acceptable acids or pharmaceutically acceptable basic compounds. In structural formula (1), A is a direct bond, a lower alkylene group or lower alkylidene group, X is an oxygen or sulphur atom, the bond between positions 3 and 4 of the carbostyril backbone is a single bond or a double bond, R⁴ and R⁵ each denotes a hydrogen atom provided that, when the bond between positions 3 and 4 of the carbostyril backbone is a double bond, R⁴ and R⁵ can instead be bonded to each other in form of a -CH=CH-CH=CH- group, and R¹, R² and R³ assume values given in the claims.

EFFECT: high efficiency of compositions based on said compounds.

32 cl, 23 dwg, 184 tbl, 1535 ex