DIAGNOSTIC TECHNIQUE FOR PERSISTENT LATENT BACTERIAL INFECTION WITH ASSOCIATING VESSEL WALL INVOLVEMENT Russian patent published in 2011 - IPC G01N33/569 

FIELD: medicine.

SUBSTANCE: after provisional diagnosing of a vascular disease, patient's blood serum is analysed for beta2-glycoprotein 1 antibodies (B2GPab), endothelium antibodies (Eab), Clq complement factor antibodies (Clq ab), cryoglobulins (CG) in the form of cryocrit and activity of rheumatoid factor (RF). If B2GPab is equal to 5 standard unit/ml and more, Eab is equal to 1:10 and more, Clq ab is equal to 5 standard unit/ml and more, CG in the form of cryocrit is more than 0%, RF is equal to 1:20 and more, therapeutic intervention which involves four daily procedures of leucopheresis with klion autoleukocyte adsorption in a single dose 500 mg combined with oral administration of biseptol in a single dose 480 mg is executed. After 4-5 weeks from the beginning of therapy, control blood examination for infection agents with the use of culture and genetic diagnostic techniques follows. If observing bacterial agents, persistent latent bacterial infection with associating vessel wall involvement is diagnosed.

EFFECT: higher diagnostic accuracy of chronic latent bacterial infection with associating vessel wall involvement.

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