METHOD OF PREVENTING CONTRAST-INDUCED NEPHROPATHY DURING RADIO-OPAQUE EXAMINATION Russian patent published in 2011 - IPC A61K31/194 A61K31/455 A61K31/525 A61K31/5375 A61P13/00 

Abstract RU 2414896 C1

FIELD: medicine.

SUBSTANCE: invention relates to medicine, in particular to radiology and nephrology, and can be applied for prevention of contrast-induced nephropathy before carrying out radio-opaque examination. For this purpose introduced is cytoflavin in dose 1 pill 3 times per day 2-5 days before carrying out radio-opaque examination.

EFFECT: method makes it possible to protect cells of renal channels from toxic action of radio-opaque combination due to improvement of energy processes in cells and tissues by regulation of two most important stages of Krebs cycle: including pyruvic acid and its oxidation to acetyl CoA, as well as oxidative decarboxylation of a-ketoglutaric acid, which results in reduction of depression of activity of succinate dehydrogenase of peripheral blood lymphocytes.

2 dwg, 2 ex

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RU 2 414 896 C1

Authors

Tsygina Elena Nikolaevna

Petrichuk Svetlana Valentinovna

Semenova Galina Fedorovna

Izmajlova Tat'Jana Dmitrievna

Kurbatova Ol'Ga Vladimirovna

Tsygin Aleksej Nikolaevich

Zorkin Sergej Nikolaevich

Jatsyk Sergej Pavlovich

Dates

2011-03-27Published

2009-12-17Filed