METHOD OF ESTIMATING NEPHROTOXIC IMPACT OF ROENTGENOPAQUE PREPARATIONS Russian patent published in 2009 - IPC A61K51/00 

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to radionuclide diagnostics. Radionuclide rhinoscintigraphy with ^99mTc-pentatech is carried out. Indices of filtering and avacuatory kidney functions are determined twice: before and 2-3 days after procedure with introduction to patient of reontgenopaque compound. Determined are slight disturbance of filtering function of kidney with less than 15% of initial value reduction of glomerular filtration, moderate disturbance of filtering function of kidney with from 15 to 30% of initial value reduction of glomerular filtration rate and expressed disturbance of filtering function of kidney with higher than 30% of initial value reduction of glomerular filtration rate. Less than 6 min from initial value increase of period of radiopharmpreparation semiejection is estimated as slight disturbance of evacuatory function of kidneys, from 6 to 15 min - as moderate disturbance of evacuatory function of kidneys and more than 15 min as expressed disturbance of evacuatory function of kidneys.

EFFECT: method ensures objective estimation of nephrotoxic impact of definite reontgenopaque compound and possibility of timely administering adequate therapy.

6 dwg, 6 ex