FIELD: medicine, pharmaceutics.
SUBSTANCE: invention refers to agents for instrumental examinations and treatment of urological diseases of various aetiology. Offered is a water-soluble organosilicon glycerin derivative exhibiting transmucous activity, with composition of excess glycerin (CH3)2Si[O-CH2-CH(OH)-CH2-OH]2×HO-CH2-CH(OH)-CH2-OH where 0.25≤x≤0.40; prepared by reaction of dimethyldiethoxysilane and glycerin at the mole ratio 1.00:(1.96-2.09) when the reaction mass heated to 120-130°C, kept at said temperature for at least 4 hours in through mixing to remove thereafter formed ethyl alcohol. Also, offered is a pharmaceutical composition containing (wt %) lidocaine hydrochloride (0.50-1.00), at least one medicinal additive (0.01-1.20), and a hydrophilic base in the form of said water-soluble organosilicon glycerin derivative (the rest - up to 100). As a medicinal additive, the pharmaceutical composition can contain (wt % of total): chlorhexidine bigluconate (0.01-0.05), or chlorhexidine bigluconate (0.01-0.05), No-spa (0.50-1.00) and ciprofloxacin (0.10-0.15), or No-spa (0.50-1.00), ciprofloxacin (0.10-0.15) and cornam (0.025-0.05).
EFFECT: preparation of the pharmaceutical composition which is applicable as a local agent for examination and treatment in urology exhibiting high penetrative activity and providing effective drug transport through a mucous membrane, exhibiting good sliding and lubricating properties.
3 cl, 2 tbl, 6 ex
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Authors
Dates
2011-03-27—Published
2009-01-26—Filed