WATER-SOLUBLE ORGANOSILICON GLYCERIN DERIVATIVE EXHIBITING TRANSMUCOUS ACTIVITY, AND BASED PHARMACEUTICAL COMPOSITION Russian patent published in 2011 - IPC C07F7/18 A61K47/24 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to agents for instrumental examinations and treatment of urological diseases of various aetiology. Offered is a water-soluble organosilicon glycerin derivative exhibiting transmucous activity, with composition of excess glycerin (CH₃)₂Si[O-CH₂-CH(OH)-CH₂-OH]₂×HO-CH₂-CH(OH)-CH₂-OH where 0.25≤x≤0.40; prepared by reaction of dimethyldiethoxysilane and glycerin at the mole ratio 1.00:(1.96-2.09) when the reaction mass heated to 120-130°C, kept at said temperature for at least 4 hours in through mixing to remove thereafter formed ethyl alcohol. Also, offered is a pharmaceutical composition containing (wt %) lidocaine hydrochloride (0.50-1.00), at least one medicinal additive (0.01-1.20), and a hydrophilic base in the form of said water-soluble organosilicon glycerin derivative (the rest - up to 100). As a medicinal additive, the pharmaceutical composition can contain (wt % of total): chlorhexidine bigluconate (0.01-0.05), or chlorhexidine bigluconate (0.01-0.05), No-spa (0.50-1.00) and ciprofloxacin (0.10-0.15), or No-spa (0.50-1.00), ciprofloxacin (0.10-0.15) and cornam (0.025-0.05).

EFFECT: preparation of the pharmaceutical composition which is applicable as a local agent for examination and treatment in urology exhibiting high penetrative activity and providing effective drug transport through a mucous membrane, exhibiting good sliding and lubricating properties.

3 cl, 2 tbl, 6 ex