FIELD: medicine.
SUBSTANCE: described is a method for producing conditionally live HIV-1 virions by means of which viral DNA or RNA are modified so that to make virion unable to replication provided a protein supplement has not been added to an expression system. The expression system represents either a conventional cell culture, or a cell-free and vector-free expression system effective in viral particle self-assembly. Both expression systems require viral proteins to be added either for replication, or for assembly of the virion unable to replicaton. The conditionally live virion is used thereafter for creating an immunogenic composition.
EFFECT: highly safe immunogenic composition exhibiting the efficacy of a live vaccine which is capable to elicit a Th-1 mediated immune response.
23 cl, 2 dwg
| Title |
Year |
Author |
Number |
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|
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|
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- Dehvid B. Vejner
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- Bin Vang
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- Vinsent R. Zuravski Ml.
|
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|
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- Chang Jung-Nien
- Lu Ksiaobin
- Slepushkin Vladimir
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- Dehvis Brajan
- Ju Kviao
- Jang Janping
- Merling Rehndall
- Khan Vej
- Ni Jadzin
- Li Juehksia
- Dropulik Boro
|
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- Johnson, Sabine
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|
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|
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- Drop'Julik Boro
- Piza Paula M.
|
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|
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|
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