FIELD: biotechnology.
SUBSTANCE: described is a method of producing microvesicle, containing a transgenic product and / or lentiviral RNA containing a transgene. Culturing human cells, wherein lentiviral vectors in vitro introducing a transgene for extracellular release microvesicle, containing a transgenic product and / or lentiviral RNA containing a transgene. At that, said lentiviral vector is deficient in at least one gene of structural protein selected from env, gag and pol genes, and contains a transgene under the control of the telomerase reverse transcriptase (TERT) gene promoter in lentiviral genomic sequence. Besides, said lentiviral RNA specified lentiviral vector and said lentiviral genomic sequence is HIV RNA, HIV vector and genomic HIV sequence, respectively. Collected released microvesicles. Invention also relates to microvester, obtained using said method, and use thereof.
EFFECT: invention widens range of agents for treating cancer.
17 cl, 20 dwg, 2 tbl, 14 ex
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