COMPOSITIONS WHICH CONTAIN EPOTHILONE, AND METHOD OF THEIR OBTAINING Russian patent published in 2011 - IPC A61K31/429 A61K9/19 A61K47/40 A61P35/00 A61J3/02 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to composition for treatment of malignant neoplasm in patient, which contains epothilone - (1S, 3S, 7S, 10R, 11S, 12S, 16K)-7,11-dihydroxy-3-(2-methyl-benzotiasol-5-yl)-10-(prop-2-en-1-yl)-8,8,12,16-tetramethyl-4,17-dioxabicyclo[14.1.0]heptadecan-5,9-dion, hydroxypropyl-β-cyclodextrine or simple sulphobutyl ether of β-cyclodextrine and fillers, selected from mannitol and trometamol. Invention also relates to method of claimed composition obtaining, which includes dissolving epothilone in alcohol, dissolving hydroxypropyl-β-cyclodextrine or simple sulphobuthyl ether of β-cyclodextrine in water solution together with mannitol and trometamol, bringing pH of water solution to value 5-9 by means of hydrochloric acid and mixing obtained solutions.

EFFECT: invention also relates to method of malignant neoplasm treatment in patient, which includes intravenous infusion of claimed composition during period of approximately 30 minutes in dose from 10 mg/m² to 35 mg/m².

17 cl, 11 ex, 2 dwg