DERIVATIVES OF EPOTHILONE Russian patent published in 2003 - IPC

FIELD: organic chemistry, medicine, pharmacy. SUBSTANCE: invention relates to novel derivatives of epothilone of the formula: wherein Q is taken among group including: wherein R₈ is hydrogen atom, alkyl; G is R₁₁ wherein R₁₂ is alkyl, heterocycle; is hydrogen atom; W represents oxygen atom or NR₁₅ wherein R₁₅ is hydrogen atom; Y = X and represents oxygen atom; Z₁ and Z₂ represent -CH₂; B₁ and B₂ mean OH; R₁-R₇ mean hydrogen atom, alkyl. Invention relates also to their pharmaceutically acceptable salts, geometrical, optical isomers and stereoisomers under condition that compounds where W and X both represent oxygen atom and R₁,R₂,R₇ represent hydrogen atom; R₃,R₄,R₆ represent methyl group; R₈ re[resents hydrogen atom or methyl group; Z₁ and Z₂ represent CH₂; G represents 1-methyl-3-(substituted-3- thiazolyl)- ethenyl; Q as indicated above are excluded. Invention relates also to method for cancer treatment, diseases associated with hyperproliferation of cells and to method providing anti- angiogenesis effect in patient. EFFECT: valuable medicinal properties of compounds. 6 cl, 2 tbl, 2 dwg, 8 ex