BENZOQUINAZOLINE DERIVATIVES AND USE THEREOF IN TREATING BONE DISORDERS Russian patent published in 2011 - IPC C07D217/12 C07D217/26 C07D239/72 C07D401/06 C07D401/12 C07D403/06 C07D403/12 C07D405/06 C07D405/12 C07D409/06 C07D409/12 C07D417/06 C07D417/12 A61K31/395 A61K31/435 A61K31/517 A61P5/18 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or pharmaceutically acceptable salts thereof, where Q is CH or N; R2 is C₁-C₄ alkyl or C₃-C₄-cycloalkyl; Y is R5-O; where R5 is propynyl; X is selected from a group consisting of aryl, heteroaryl, C₁-C₅-alkyloxy, heterocycloalkyl, arylamino, heteroarylamino, heteroaryl-C₁-C₄-alkylamino, aryloxy, aryl-C₁-C₂-alkyloxy or C₃-C₆-cycloalkyl-C₁-C₄-alkyloxy, each of which is optionally substituted with 1-3 times; the optional substitute(s) for X is(are) independently selected from a group comprising halogen, cyano, trifluoromethyl, nitro, hydroxy, C₁-C₄-alkyl, C₁-C₄-alkoxy, C₁-C₄-alkyloxy-C₁-C₄-alkoxy, -SMe, SO₂-C₁-C₂-alkyl, -NMe₂, - C(O)O-C₁-C₅-alkyl, -SCF₃, -SO₂-NH₂, -SO₂-C₂-alkyl-OH, -CONH₂, -COMe, - CONH-C₁-C₄-alkyl, -CONMe₂, -NHCOMe, -CH₂COOEt, -OCH₂COOEt, -CH₂- cyclopropyl, and each R3 and R4 is H; where aryl denotes phenyl or naphthyl; heteroaryl denotes monocyclic or bicyclic hydrocarbon containing 5-10 ring atoms, one or more of which are heteroatoms selected from O, N or S; heterocyclyl denotes piperidinyl or benzodioxolyl; or a compound or pharmaceutically acceptable salt thereof, selected from a group comprising (4-dimethylaminophenyl)-[4-(4-cyclopropylphenyl)-6-propargyloxyquinazolin-2-yl]methanone, (3-sulphamoylphenyl)amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4-dihydroquinazoline-2-carboxylic acid, [3-(2-hydroxyethanesulphonyl)phenyl]amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4-dihydroquinazoline-2-carboxylic acid, (3-methylsulphanylphenyl)amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4-dihydroquinazoline-2-carboxylic acid, (3-methanesulphonylphenyl)amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4-dihydroquinazoline-2-carboxylic acid, and (5-ethanesulphonyl-2-hydroxyphenyl)amide 4-(4-isopropylphenyl)-6-prop-2-ynyloxy-3,4- dihydroquinazoline -2-carboxylic acid. The invention also relates to a pharmaceutical composition based on the compound of formula (I) and use of the compound of formula (I).

EFFECT: novel benzoquinazoline derivatives, which are useful in treating bone disorders, are obtained.

6 cl, 128 ex