FIELD: chemistry.
SUBSTANCE: invention relates to an improved method of producing dihydroquinazolines of formula (I), which are used to prepare medicinal agents. In formula
Ar denotes phenyl, possibly substituted with a C1-C4alkoxy group, R1 and R2 are selected from hydrogen, C1-C4alkoxy group and trifluoromethyl, R3 is selected from C1-C4 alkoxy group and trifluoromethyl, R4 denotes hydrogen or C1-C4alkyl, R5 denotes hydrogen or C1-C4alkyl, each of R6 R7 and R8 denotes hydrogen or halogen. The method involves hydrolysis of an ester of a compound of formula (II) in which Ar, R1, R2, R3, R4, R5, R6, R7 and R8 are as described above and R9 denotes C1-C4-alkyl, with a base or acid, where the compound of formula (II) obtained from reaction of a compound
of formula (III), is used, in which R1, R2, R3, R6, R7 and R8 are as described above and R9 denotes C1-C4-alkyl, in the presence of a base, with a compound of formula (IV) in which Ar, R4 and R5 are as described above. The method simplifies extraction of products.
EFFECT: invention also relates to novel intermediate compounds and a method of obtaining said compounds.
11 cl, 5 dwg, 24 ex
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